Efficacy and tolerability of a novel herbal formulation for weight management

Authors

  • J.S. Stern,

    Corresponding author
    1. Department of Nutrition, University of California Davis, Davis, California, USA
    2. Department of Internal Medicine, University of California Davis, Davis, California, USA
    • Department of Nutrition, University of California Davis, Davis, California, USA
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    • Disclosure: The authors have no ownership or intellectual property rights or any financial ties with the sponsors. The authors, not the sponsors, are responsible for data collection, analysis and interpretation as well as manuscript preparation. The sponsors were aware of the study design which determined the budget and underwriting of the project.

  • J. Peerson,

    1. Program in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, California, USA
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  • A.T. Mishra,

    1. Department of General Medicine, Nagarjuna Hospitals, Vijayawada, Andhra Pradesh, India
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  • M.V. Sadasiva Rao,

    1. Department of Internal Medicine, Alluri Sitarama Raju Academy of Medical Sciences (ASRAM), Eluru, Andhra Pradesh, India
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  • K.P. Rajeswari

    1. Suraksha Health Village, Gurunanak Nagar, Vijayawada, Andhra Pradesh, India
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  • Funding agencies: This research was supported by the InterHealth Nutraceuticals Inc.

Abstract

Objective:

To evaluate the efficacy of an herbal blend.

Design and Methods:

A randomized, double-blind, clinical trial in 60 subjects with body mass index (BMI) between 30 and 40 kg/m2. Participants were randomized into two groups receiving either 400 mg herbal capsules or 400 mg placebo capsules twice daily. The herbal blend comprises of extracts from Sphaeranthus indicus and Garcinia mangostana. Participants received a standard diet (2,000 kcal per day) and walked 30 min 5 days per week.

Results:

After 8 weeks, significant net reductions in body weight (3.74 kg; P < 0.0001), BMI (1.61 kg/m2; P < 0.0001), and waist circumference (5.44 cm; P < 0.05) were observed in the herbal group compared with placebo. Additionally, a significant increase in serum adiponectin concentration was found in the herbal group versus placebo (P = 0.001). Adverse events were mild and were equally distributed between the two groups. In vitro studies in the 3T3-L1 adipocyte cell line showed that the herbal extract markedly downregulated the expression of peroxisome proliferator-activated receptor gamma, adipocyte-differentiation related protein, and cluster of differentiation 36 but increased adiponectin expression. The herbal extract also reduced the expression and the recruitment of perilipin onto the membrane of lipid droplets.

Conclusion:

Supplementation with the herbal blend resulted in a greater degree of weight loss than placebo over 8 weeks.

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