Funding agencies: This research was supported by the grant (K01-DK083029) Mentored Research Scientist Development Award from the National Institute of Diabetes and Digestive and Kidney Diseases, grant (T32-HL083825) Postdoctoral Institutional Training Award from the National Heart, Lung, and Blood Institute, grant (R03-AR050107 and R01-AR049747) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, as well as Division of Health and Social Services and Tobago House of Assembly.
Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men
Article first published online: 13 MAY 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 9, pages 1900–1907, September 2013
How to Cite
Miljkovic, I., Kuipers, A.L., Kuller, L.H., Sheu, Y., Bunker, C.H., Patrick, A.L., Wheeler, V.W., Evans, R.W. and Zmuda, J.M. (2013), Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men. Obesity, 21: 1900–1907. doi: 10.1002/oby.20214
Disclosure: The authors declared no conflict of interest.
- Issue published online: 23 SEP 2013
- Article first published online: 13 MAY 2013
- Accepted manuscript online: 17 JAN 2013 11:23PM EST
- Manuscript Accepted: 18 NOV 2012
- Manuscript Received: 17 OCT 2011
- Mentored Research Scientist Development Award. Grant Number: K01-DK083029
- National Institute of Diabetes and Digestive and Kidney Diseases. Grant Number: T32-HL083825
- Postdoctoral Institutional Training Award
- National Heart, Lung, and Blood Institute. Grant Numbers: R03-AR050107, R01-AR049747
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Division of Health and Social Services
- Tobago House of Assembly
Objective: When compared with other ethnic groups, African ancestry individuals have lower triglycerides and higher High-density lipoprotein cholesterol (HDL-C) levels, although the mechanisms for these differences remain unclear. A comprehensive array of factors potentially related to fasting serum lipid and lipoprotein levels in African ancestry men was evaluated.
Design and Methods: Men (1,821) underwent dual-energy X-ray absorptiometry measures of total body fat and quantitative computed tomography assessments of calf skeletal muscle adiposity [subcutaneous and intermuscular adipose tissue (AT), and muscle density as a measure of intra-muscular AT].
Results: Multivariable linear regression analysis identified age (−), total body fat (+), subcutaneous AT (−), fasting glucose (+), fasting insulin (+), diastolic blood pressure (+), and non-African ancestry (+) as independent correlates of triglycerides (all P < 0.05). Total body fat (+), intra-muscular AT (−), and diastolic blood pressure (+) were independent correlates of Low-density lipoprotein cholesterol (LDL-C) (all P < 0.001). Age (+), waist circumference (−), fasting insulin (−), physical activity (+), and alcohol intake (+) were independent correlates of HDL-C (all P < 0.05).
Conclusions: A novel relationship between skeletal muscle adiposity and serum lipid and lipoprotein levels in African ancestry men, independent of total and central adiposity was illuminated. In African ancestry populations, genetic factors are likely a significant determinant of triglycerides levels.