Abdominal visceral fat measurement using dual-energy X-ray: Association with cardiometabolic risk factors

Authors


  • Funding agencies: The study was supported in part by a grant from the Italian Society for the Study of Atherosclerosis Lombardy Chapter (SISA). GE Healthcare funded a portion of this project related to data acquisition and data analysis.

  • Disclosure: MPR, JX, WKW, YX, and DLE are employees of GE Healthcare or its affiliates. No other potential conflicts of interest related to this article were reported.

Correspondence: David L. Ergun(ergundavid@gmail.com)

Abstract

Objective

To examine the association between cardiometabolic risk factors and visceral adipose tissue (VAT) measurements using a dual-energy X-ray absorptiometry (DXA) based approach.

Design and Methods

An analysis of cross-sectional relationships between DXA VAT measured using CoreScan (GE Healthcare) and cardiometabolic indicators was conducted on a sample of 939 subjects (541 females and 398 males; average age, 56 years; average BMI, 26 kg/m2) who had previously undergone a total body DXA scan as well as measurements of key cardiometabolic risk factors.

Results

Sex-specific, age-adjusted multivariable regression analysis showed that for both men and women, DXA VAT was significantly associated with increased odds of hypertension, impaired fasting glucose, metabolic syndrome, and type 2 diabetes (P < 0.001). After additional model adjustment for BMI and waist circumference, the odds ratio (per SD change in VAT) for type 2 diabetes was 2.07 for women and 2.25 for men. Similarly, the odds ratio for metabolic syndrome for women was 3.46 and for men was 1.75.

Conclusions

VAT measured using DXA showed a significant association with cardiometabolic risk factors and disease. These relationships persist after statistical adjustment for age, BMI, and waist circumference. DXA VAT may provide a new accessible option for quantifying VAT-related cardiometabolic risk.

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