No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I
Article first published online: 21 MAY 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 9, pages 1803–1806, September 2013
How to Cite
Thomsen, G., Ziebell, M., Jensen, P. S., da Cuhna-Bang, S., Knudsen, G. M. and Pinborg, L. H. (2013), No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I. Obesity, 21: 1803–1806. doi: 10.1002/oby.20225
- Issue published online: 23 SEP 2013
- Article first published online: 21 MAY 2013
- Accepted manuscript online: 12 DEC 2012 11:16AM EST
- Manuscript Accepted: 19 NOV 2012
- Manuscript Received: 19 JUN 2012
- Dopamine transporter
Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values.
Design and Methods
Thirty-three healthy subjects with a mean age of 48.4 ± 13.3 (range, 21-71) years and a mean BMI of 29.6 ± 7.8 kg/m2 (range, 21.0-49.5) were included in the study. We used [123I]PE2I and SPECT to measure DAT availability.
Using multiple linear regression analyses with striatal DAT as the dependent variable and BMI, age and gender as predictors was performed. We found no correlation between BMI and striatal DAT availability in striatum (P = 0.99), caudate nucleus (P = 0.61), and putamen (P = 0.30). Furthermore, we found no group difference between obese/severely obese (BMI > 30 kg/m2) and normal weight controls (BMI ≤ 25 kg/m2).
We did not find any correlation between BMI and DAT availability in healthy volunteers.