Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women

Authors

  • Timothy D. Heden,

    1. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
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  • Ying Liu,

    1. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
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  • Lauren J. Sims,

    1. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
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  • Adam T. Whaley-Connell,

    1. Harry S Truman VA Medical Center, University of Missouri, Columbia, Missouri, USA
    2. Department of Internal Medicine, Division of Nephrology, University of Missouri, Columbia, Missouri, USA
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  • Anand Chockalingam,

    1. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Missouri, Columbia, Missouri, USA
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  • Kevin C. Dellsperger,

    1. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Missouri, Columbia, Missouri, USA
    2. Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
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  • Jill A. Kanaley

    Corresponding author
    1. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.
    • Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA;
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Abstract

Objective:

The aim of this study was to compare postprandial lipemia, oxidative stress, antioxidant activity, and insulinemia between a three and six isocaloric high-carbohydrate meal frequency pattern in obese women.

Design and Methods:

In a counterbalanced order, eight obese women completed two, 12-h conditions in which they consumed 1,500 calories (14% protein, 21% fat, and 65% carbohydrate) either as three 500 calorie liquid meals every 4-h or six 250 calorie liquid meals every 2-h. Blood samples were taken every 30 min and analyzed for triacylglycerol (TAG), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, oxidized low-density lipoprotein cholesterol, myeloperoxidase, paraoxonase-1 activity, and insulin.

Results:

The TAG incremental area under the curve (iAUC) during the three meal condition (321 ± 129 mg/dl·12 h) was significantly lower (P = 0.04) compared with the six meal condition (481 ± 155 mg/dl·12 h). The insulin iAUC during the three meal condition (5,549 ± 1,007 pmol/l.12 h) was significantly higher (P = 0.05) compared with the six meal condition (4,230 ± 757 pmol/l.12 h). Meal frequency had no influence on the other biochemical variables.

Conclusions:

Collectively, a three and six isocaloric high-carbohydrate meal frequency pattern differentially alters postprandial TAG and insulin concentrations but has no effect on postprandial cholesterol, oxidative stress, or antioxidant activity in obese women.

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