Disclosure: The authors declared no conflict of interest. See the online ICMJE Conflict of Interest Forms for this article.
Obesity and body fat classification in the metabolic syndrome: Impact on cardiometabolic risk metabotype†
Article first published online: 16 MAR 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 1, pages E154–E161, January 2013
How to Cite
Phillips, C. M., Tierney, A. C., Perez-Martinez, P., Defoort, C., Blaak, E. E., Gjelstad, I. M. F., Lopez-Miranda, J., Kiec-Klimczak, M., Malczewska-Malec, M., Drevon, C. A., Hall, W., Lovegrove, J. A., Karlstrom, B., Risérus, U. and Roche, H. M. (2013), Obesity and body fat classification in the metabolic syndrome: Impact on cardiometabolic risk metabotype. Obesity, 21: E154–E161. doi: 10.1002/oby.20263
- Issue published online: 16 MAR 2013
- Article first published online: 16 MAR 2013
- Manuscript Accepted: 31 MAY 2012
- Manuscript Received: 13 JAN 2012
Obesity is a key factor in the development of the metabolic syndrome (MetS), which is associated with increased cardiometabolic risk. We investigated whether obesity classification by BMI and body fat percentage (BF%) influences cardiometabolic profile and dietary responsiveness in 486 MetS subjects (LIPGENE dietary intervention study).
Design and Methods:
Anthropometric measures, markers of inflammation and glucose metabolism, lipid profiles, adhesion molecules, and hemostatic factors were determined at baseline and after 12 weeks of four dietary interventions (high saturated fat (SFA), high monounsaturated fat (MUFA), and two low fat high complex carbohydrate (LFHCC) diets, one supplemented with long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs)).
About 39 and 87% of subjects classified as normal and overweight by BMI were obese according to their BF%. Individuals classified as obese by BMI (≥30 kg/m2) and BF% (≥25% (men) and ≥35% (women)) (OO, n = 284) had larger waist and hip measurements, higher BMI and were heavier (P < 0.001) than those classified as nonobese by BMI but obese by BF% (NOO, n = 92). OO individuals displayed a more proinflammatory (higher C reactive protein (CRP) and leptin), prothrombotic (higher plasminogen activator inhibitor-1 (PAI-1)), proatherogenic (higher leptin/adiponectin ratio) and more insulin resistant (higher HOMA-IR) metabolic profile relative to the NOO group (P < 0.001). Interestingly, tumor necrosis factor-α (TNF-α) concentrations were lower post-intervention in NOO individuals compared with OO subjects (P < 0.001).
In conclusion, assessing BF% and BMI as part of a metabotype may help to identify individuals at greater cardiometabolic risk than BMI alone.