The first two authors contributed equally to the work.
Serum hemorphin-7 levels are decreased in obesity†
Article first published online: 27 MAR 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 2, pages 378–381, February 2013
How to Cite
Maraninchi, M., Feron, D., Fruitier-Arnaudin, I., Bégu-Le Corroller, A., Nogueira, J. P., Mancini, J., Valéro, R., Piot, J. M. and Vialettes, B. (2013), Serum hemorphin-7 levels are decreased in obesity. Obesity, 21: 378–381. doi: 10.1002/oby.20280
Disclosure: The authors declared no conflict of interest.
See the online ICMJE Conflict of Interest Forms for this article.
- Issue published online: 27 MAR 2013
- Article first published online: 27 MAR 2013
- Manuscript Accepted: 31 MAY 2012
- Manuscript Received: 11 NOV 2011
Hemorphin peptides exhibit biological activities that interfere with the endorphin system, the inflammatory response, and blood-pressure control. VV-hemorphin-7 and LVV-hemorphin-7 peptides exert a hypotensive effect, in particular, by inhibiting the renin–angiotensin system. Furthermore, levels of circulating hemorphin-7 peptides have been found to be decreased in diseases such as type 1 and type 2 diabetes.
Design and Methods:
Because type 2 diabetes and obesity share common features, such as insulin resistance, microinflammation, high glomerular-filtration rate (GFR), and cardiovascular risk, we evaluated serum VV-hemorphin-7 like immunoreactivity (VVH7-i.r.) levels, using an enzyme-linked immunosorbent assay method, on a group of 54 obese subjects without diabetes or hypertension, compared with a group of 33 healthy normal-weight subjects.
Circulating VVH7-i.r. levels were significantly decreased in the obese group compared with the control group (1.98 ± 0.19 vs. 4.86 ± 0.54 µmol/l, respectively, P < 0.01), and a significant negative correlation between VVH7-i.r. and diastolic blood pressure (DBP) was found in obese patients (r = −0.35, P = 0.011). There was no significant correlation between VVH7-i.r. level and insulin resistance, metabolic syndrome, or GFR.
The decreased serum hemorphin-7 found in obese subjects, as in diabetes, may contribute to the development of hypertension and to the cardiovascular risk associated with these metabolic diseases.