Early changes of abdominal adiposity detected with weekly dual bioelectrical impedance analysis during calorie restriction


  • Disclosure: The authors declared no conflict of interest.

  • Funding agencies: This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan including Grant in Aid for Scientific Research on Innovative Areas (Research in a proposed research area) “Molecular Basis and Disorders of Control of Appetite and Fat Accumulation”, the Ministry of Health, Labour and Welfare of Japan, the Takeda Medical Research Foundation, the Smoking Research Foundation, Suzuken Memorial Foundation, Japan Foundation of Applied Enzymology, Novo Nordisk Insulin Research Award, Lilly Education and Research Grant Office.

Correspondence: Masakazu Hirata (mhirata@kuhp.kyoto-u.ac.jp)



To elucidate early change of intra-abdominal fat in response to calorie restriction in patients with obesity by weekly evaluation using a dual bioelectrical impedance analysis (Dual BIA) instrument.


For 67 Japanese patients with obesity, diabetes, or metabolic syndrome, intra-abdominal fat area (IAFA), initially with both Dual BIA and computed tomography (CT), and in subsequent weeks of calorie restriction, with Dual BIA were measured.


IAFA by Dual BIA (Dual BIA-IAFA) correlated well with IAFA by CT (CT-IAFA) in obese patients (r = 0.821, P < .0001, n = 67). Ten males and 9 females (age 49.0 ± 14.4 years, BMI 33.2 ± 7.3 kg/m2) lost more than 5% of baseline body weight (BW) in 3 weeks, and their Dual BIA-IAFA, BW, and WC decreased by 18.9%, 5.3%, and 3.8%, respectively (P < .05, ANCOVA).


Dual BIA instrument could detect the weekly change of Dual BIA-IAFA under calorie restriction in obese patients and demonstrated a substantially larger change of IAFA compared with changes of BW and WC in early weeks. This observation corroborates the significance of evaluating IAFA as a biomarker for obesity, and indicates the clinical usefulness of the Dual BIA instrument.