Funding/Support: The Jackson Heart Study and the Framingham Heart Study are supported by the National Heart, Lung, and Blood Institute, and the National Center on Minority Health and Health Disparities (N01-HC-95170, N01-HC-95171, N01-C-95172 and N01-HC-25195).
Differential associations of abdominal visceral, subcutaneous adipose tissue with cardiometabolic risk factors between African and European Americans
Article first published online: 11 FEB 2014
Copyright © 2013 The Obesity Society
Volume 22, Issue 3, pages 811–818, March 2014
How to Cite
Liu, J., Coady, S., Carr, J. J., Hoffmann, U., Taylor, H. A. and Fox, C. S. (2014), Differential associations of abdominal visceral, subcutaneous adipose tissue with cardiometabolic risk factors between African and European Americans. Obesity, 22: 811–818. doi: 10.1002/oby.20307
Disclosure: The authors declared no conflict of interest.
Author Contributions: Dr. Coady had full access to all of the data in the study and takes responsibility for integrity of the data and accuracy of data analysis. Study Concept and Design: Drs. Liu, Fox and Taylor. Acquisition and Analysis of data: Dr. Fox, Dr. Coady. Interpretation of data: Drs. Liu, Fox, Coady, and Taylor. Manuscript drafting: Drs. Liu, Fox. Critical revisions of the manuscript for important intellectual content: Drs. Fox, Hoffmann, Taylor, Carr, Liu and Coady.
- Issue published online: 5 MAR 2014
- Article first published online: 11 FEB 2014
- Accepted manuscript online: 14 FEB 2013 07:12AM EST
- Manuscript Accepted: 30 NOV 2012
- Manuscript Revised: 16 NOV 2012
- Manuscript Received: 2 MAY 2012
To examine the relative association of abdominal visceral adipose tissue (VAT) with cardiometabolic risk factors between African and European Americans.
A cross-sectional study of 2,035 African Americans from the Jackson Heart Study (JHS) and 3,170 European Americans from the Framingham Heart Study (FHS) who underwent computed tomography assessment of VAT and subcutaneous adipose tissue (SAT) was conducted. The FHS participants were weighted to match the age distribution of the JHS participants, and the metabolic risk factors were examined by study groups in relation to VAT.
JHS participants had higher rates of obesity, hypertension, diabetes, and metabolic syndrome than FHS participants (all P = 0.001). The associations were weaker in JHS women for VAT with blood pressure, triglycerides, HDL-C, and total cholesterol (Pinteraction = 0.03-0.001) than FHS women. In contrast, JHS men had stronger associations for VAT with high triglycerides, low HDL, and metabolic syndrome (all Pinteraction = 0.001) compared to FHS men. Similar associations and gender patterns existed for SAT with most metabolic risk factors.
The relative association between VAT and cardiometabolic risk factors is weaker in JHS women compared to FHS women, whereas stronger associations with triglycerides and HDL were observed in JHS men.