Disclosure: The authors have no conflicts of interest to disclose.
Differential associations of leptin with adiposity across early childhood
Article first published online: 25 MAY 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 7, pages 1430–1437, July 2013
How to Cite
Boeke, C. E., Mantzoros, C. S., Hughes, M. D., L. Rifas-Shiman, S., Villamor, E., Zera, C. A. and Gillman, M. W. (2013), Differential associations of leptin with adiposity across early childhood. Obesity, 21: 1430–1437. doi: 10.1002/oby.20314
- Issue published online: 12 AUG 2013
- Article first published online: 25 MAY 2013
- Accepted manuscript online: 14 FEB 2013 07:14AM EST
- Manuscript Accepted: 6 DEC 2012
- Manuscript Received: 1 OCT 2012
To examine associations of perinatal and 3-year leptin with weight gain and adiposity through 7 years.
Design and Methods
In Project Viva, plasma leptin from mothers at 26-28 weeks' gestation (n = 893), umbilical cord vein at delivery (n = 540), and children at 3 years (n = 510) was assessed in relation to BMI z-score, waist circumference, skinfold thicknesses, and dual X-ray absorptiometry body fat.
50.1% of children were male and 29.5% non-white. Mean (SD) maternal, cord, and age 3 leptin concentrations were 22.9 (14.2), 8.8 (6.4), and 1.8 (1.7) ng/ml, respectively, and 3- and 7-year BMI z-scores were 0.46 (1.00) and 0.35 (0.97), respectively. After adjusting for parental and child characteristics, higher maternal and cord leptin were associated with less 3-year adiposity. For example, mean 3-year BMI z-score was 0.5 lower (95% CI: −0.7, −0.2; P-trend = 0.003) among children whose mothers' leptin concentrations were in the top versus bottom quintile. In contrast, higher age 3 leptin was associated with greater weight gain and adiposity through age 7 [e.g., change in BMI z-score from 3 to 7 years was 0.2 units (95% CI: −0.0, 0.4; P-trend =0.05)].
Higher perinatal leptin was associated with lower 3-year adiposity, whereas higher age 3 leptin was associated with greater weight gain and adiposity by 7 years.