• 1
    Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006;444:875880.
  • 2
    Aucott L, Gray D, Rothnie H, et al. Effects of lifestyle interventions and long-term weight loss on lipid outcomes—a systematic review. Obes Rev 2011;12:e412e425.
  • 3
    Dattilo A, Kris-Etherton P. Effects of weight reduction on blood lipids and lipoproteins: a meta- analysis. Am J Clin Nutr 1992;56:320328.
  • 4
    Corella D, Ordovas JM. Single nucleotide polymorphisms that influence lipid metabolism: interaction with dietary factors. Annu Rev Nutr 2005;25:341390.
  • 5
    Hunt SC, Hasstedt SJ, Kuida H, et al. Genertic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins. Am J Epidemiol 1989;129:625638.
  • 6
    Aulchenko Y, Ripatti S, Lindqvist I, et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 2009;41:4755.
  • 7
    Kathiresan S, Melander O, Guiducci C, et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 2008;40:189197.
  • 8
    Kathiresan S, Willer CJ, Peloso GM, et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2009;41:5665.
  • 9
    Sabatti C, Service S, Hartikainen A, et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 2009;41:3546.
  • 10
    Willer CJ, Sanna S, Jackson AU, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008;40:161169.
  • 11
    Walker CG, Loos RJF, Olson AD, et al. Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids. Atherosclerosis 2011;215:421427.
  • 12
    Jebb SA, Ahern AL, Olson AD, et al. Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial. Lancet 2011;378:14851492.
  • 13
    Li S, Zhao JH, Luan JA, et al. Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med 2010;7:e1000332.
  • 14
    Wing R, Jeffery R. Effect of modest weight loss on changes in cardiovascular risk factors: are there differences between men and women or between weight loss and maintenance? Int J Obes 1995;19:6773.
  • 15
    Poobalan A, Aucott L, Smith WCS, et al. Effects of weight loss in overweight/obese individuals and long-term lipid outcomes—a systematic review. Obes Rev 2004;5:4350.
  • 16
    Leichtle AB, Helmschrodt C, Ceglarek U, et al. Effects of a 2-y dietary weight-loss intervention on cholesterol metabolism in moderately obese men. Am J Clin Nutr 2011;94:11891195.
  • 17
    Di Buono M, Hannah JS, Katzel LI, et al. Weight loss due to energy restriction suppresses cholesterol biosynthesis in overweight, mildly hypercholesterolemic men. J Nutr 1999;129:15451548.
  • 18
    Kudchodkar B, Sodhi H, Mason D, et al. Effects of acute caloric restriction on cholesterol metabolism in man. Am J Clin Nutr 1977;30:11351146.
  • 19
    Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010;466:707713.
  • 20
    Walker CG, Jebb SA. Gene–diet interactions on lipid levels: current knowledge in the era of genome-wide association studies. Curr Nutr Rep 2012;1:123131.
  • 21
    Hamrefors V, Orho-Melander M, Krauss RM, et al. A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women. J Lipid Res 2010;51:625634.
  • 22
    Sarzynski MA, Jacobson P, Rankinen T, et al. Association of GWAS-based candidate genes with HDL-cholesterol levels before and after bariatric surgery in the Swedish obese subjects study. J Clin Endocrinol Metab 2011;96:E953–E957.
  • 23
    Barber MJ, Mangravite LM, Hyde CL, et al. Genome-wide association of lipid-lowering response to statins in combined study populations. PLoS ONE 2010;5:e9763.
  • 24
    Kee F, Young IS, Poirier O, et al. Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss? Atherosclerosis 2000;153:119128.
  • 25
    Nieminen T, Matinheikki J, Nenonen A, et al. The relationship of sterol regulatory element-binding protein cleavage-activation protein and apolipoprotein E gene polymorphisms with metabolic changes during weight reduction. Metabolism 2007;56:876880.
  • 26
    Santosa S, Demonty I, Lichtenstein AH, et al. Single nucleotide polymorphisms in ABCG5 and ABCG8 are associated with changes in cholesterol metabolism during weight loss. J Lipid Res 2007;48:26072613.