Disclosure: The authors have no conflicts of interest to report.
Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans
Version of Record online: 29 MAY 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 7, pages 1370–1379, July 2013
How to Cite
Bhutani, S., Klempel, M. C., Kroeger, C. M., Trepanowski, J. F. and Varady, K. A. (2013), Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans. Obesity, 21: 1370–1379. doi: 10.1002/oby.20353
- Issue online: 12 AUG 2013
- Version of Record online: 29 MAY 2013
- Accepted manuscript online: 14 FEB 2013 07:20AM EST
- Manuscript Accepted: 4 DEC 2012
- Manuscript Received: 5 JUL 2012
- American Heart Association. Grant Number: 12PRE8350000
- University of Illinois, Chicago, Departmental funding
This study examined whether the combination of alternate day fasting (ADF) plus exercise produces superior changes in body composition and plasma lipid levels when compared to each intervention alone.
Design and Methods
Obese subjects (n = 64) were randomized to 1 of 4 groups for 12 weeks: 1) combination (ADF plus endurance exercise), 2) ADF, 3) exercise, or 4) control.
Body weight was reduced (P < 0.05) by 6 ± 4 kg, 3 ± 1 kg, and 1 ± 0 kg in the combination, ADF, and exercise groups, respectively. Fat mass and waist circumference decreased (P < 0.001), while lean mass was retained in the combination group. Low-density lipoprotein (LDL) cholesterol decreased (12 ± 5%, P < 0.05) and high-density lipoprotein (HDL) cholesterol increased (18 ± 9%, P < 0.05) in the combination group only. LDL particle size increased (P < 0.001) by 4 ± 1 Å and 5 ± 1 Å in the combination and ADF groups, respectively. The proportion of small HDL particles decreased (P < 0.01) in the combination group only.
These findings suggest that the combination produces superior changes in body weight, body composition, and lipid indicators of heart disease risk, when compared to individual treatments.