Disclosure: The authors declared no conflict of interest.
Long-term effects of weight loss after bariatric surgery on functional and structural markers of atherosclerosis
Article first published online: 25 MAY 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 10, pages 1960–1965, October 2013
How to Cite
Tschoner, A., Sturm, W., Gelsinger, C., Ress, C., Laimer, M., Engl, J., Laimer, E., Mühlmann, G., Mittermair, R., Kaser, S., Tilg, H. and Ebenbichler, C.F. (2013), Long-term effects of weight loss after bariatric surgery on functional and structural markers of atherosclerosis. Obesity, 21: 1960–1965. doi: 10.1002/oby.20357
Funding agencies: This work was supported by the Jubiläumsfond der Österreichischen Nationalbank [Grant Nr. 13211].
- Issue published online: 5 OCT 2013
- Article first published online: 25 MAY 2013
- Accepted manuscript online: 20 MAR 2013 01:54AM EST
- Manuscript Accepted: 16 DEC 2012
- Manuscript Received: 20 MAR 2012
- Jubiläumsfond der Österreichischen Nationalbank. Grant Number: 13211
Objective: Pronounced weight loss after bariatric surgery was demonstrated to have significant beneficial effects on surrogates of early atherosclerosis. The aim of this prospective examination was to investigate whether these improvements of endothelial function and vascular structure are persistent in the long-term.
Design and Methods: A total of 52 obese adults were examined before and 5 years after bariatric surgery. Carotid intima media thickness (IMT), brachial flow-mediated dilation (FMD), abdominal fat distribution, and metabolic parameters were determined. Additional 18 months data were available from 27 patients.
Results: After 5 years, mean weight loss ± SD of 25% ± 12 in all subjects was accompanied by known improvements in metabolism. Change in IMT was −0.02 mm ± 0.007, whereas FMD improved by +1.5% ± 0.5. In the subgroup IMT decreased by 0.04 mm ± 0.06 within the first 18 months, whereas no significant change was observed between 18 month and 5 years. FMD improved by 3.8% ± 0.6 after 18 months followed by a nonsignificant decrease of −1.4% ± 0.9.
Conclusions: These long-term results demonstrate that bariatric surgery-induced weight loss improves both functional and structural markers of early atherosclerosis providing further evidence for the beneficial effects of weight loss on obesity-associated alterations of the vasculature.