Disclosure: ML has done consulting work for MARS, Inc. BLM, MKL, and LFP have no conflicts of interest to report. I verify that, as corresponding author, I have in my possession, and will keep on file, ICMJE COI forms from all co-authors, and that I have compiled a COI statement that fully and accurately reflects what I and each co-author have stated on our ICMJE COI forms and have included it in the acknowledgements section of our manuscript.
Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight
Article first published online: 31 MAY 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 11, pages 2372–2376, November 2013
How to Cite
Mason, B. L., Lobo, M. K., Parada, L. F. and Lutter, M. (2013), Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight. Obesity, 21: 2372–2376. doi: 10.1002/oby.20382
Funding agencies: This work was funded by the following grants: DK081185-01, DK081182-01, MH084058-01A1, Disease Oriented Clinical Scholars Program, and NARSAD Young Investigator Award.
- Issue published online: 1 NOV 2013
- Article first published online: 31 MAY 2013
- Accepted manuscript online: 20 MAR 2013 02:10AM EST
- Manuscript Accepted: 16 DEC 2012
- Manuscript Received: 23 AUG 2012
Loss of BDNF-TrkB signaling results in obesity in both humans and mice; however, the neural circuit that mediates this effect is unknown. The role of TrkB signaling in dopamine-1 receptor expressing neurons in body weight regulation was tested.
Mice with a floxed allele of the TrkB gene were paired with mice expressing Cre-recombinase under control of the D1 promoter to conditionally knock out expression of TrkB receptors from D1-neurons.
Deletion of TrkB receptors from D1 neurons results in obesity in chow fed mice due to increased feed efficiency. In contrast, loss of Trk B signaling in D1 neurons induced hyperphagia and hyperglycemia in mice maintained on high fat diet.
These findings indicate TrkB signaling in D1 neurons regulates body weight by distinct mechanisms for chow and high fat diet and may be important for defending the body against the development of obesity and obesity-related disorders.