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References

  • 1
    Seidell JC. Epidemiology of obesity. Semin Vasc Med 2005;5:3-14.
  • 2
    Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010;303:235-241.
  • 3
    Montani JP, Antic V, Yang Z, Dulloo A. Pathways from obesity to hypertension: from the perspective of a vicious triangle. Int J Obes Relat Metab Disord 2002;26(Suppl 2):S28-S38.
  • 4
    Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 2002;162:1867-1872.
  • 5
    Hall JE, Crook ED, Jones DW, Wofford MR, Dubbert PM. Mechanisms of obesity-associated cardiovascular and renal disease. Am J Med Sci 2002;324:127-137.
  • 6
    Serne EH, de Jongh RT, Eringa EC, Ijzerman RG, Stehouwer CD. Microvascular dysfunction: a potential pathophysiological role in the metabolic syndrome. Hypertension 2007;50:204-211.
  • 7
    Zeng G, Nystrom FH, Ravichandran LV, et al.Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 2000;101:1539-1545.
  • 8
    Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006;113:1888-1904.
  • 9
    Eringa EC, Stehouwer CD, Merlijn T, Westerhof N, Sipkema P. Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles. Cardiovasc Res 2002;56:464-471.
  • 10
    Eringa EC, Stehouwer CD, Roos MH, Westerhof N, Sipkema P. Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats. Am J Physiol Endocrinol Metab 2007;293:E1134-E1139.
  • 11
    Gudbjornsdottir S, Elam M, Sellgren J, Anderson EA. Insulin increases forearm vascular resistance in obese, insulin-resistant hypertensives. J Hypertens 1996;14:91-97.
  • 12
    Clerk LH, Vincent MA, Jahn LA, Liu Z, Lindner JR, Barrett EJ. Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes 2006;55:1436-1442.
  • 13
    de Jongh RT, Serne EH, Ijzerman RG, Jorstad HT, Stehouwer CD. Impaired local microvascular vasodilatory effects of insulin and reduced skin microvascular vasomotion in obese women. Microvasc Res 2008;75:256-262.
  • 14
    de Jongh RT, Serne EH, Ijzerman RG, de Vries G, Stehouwer CD. Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation 2004;109:2529-2535.
  • 15
    Rumantir MS, Vaz M, Jennings GL et al.Neural mechanisms in human obesity-related hypertension. J Hypertens 1999;17:1125-1133.
  • 16
    Baron AD. Hemodynamic actions of insulin. Am J Physiol 1994;267(2 Pt 1):E187-E202.
  • 17
    Serne EH, Ijzerman RG, Gans RO et al.Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia. Diabetes 2002;51:1515-1522.
  • 18
    Iijima T, Aoyagi T, Iwao Y et al.Cardiac output and circulating blood volume analysis by pulse dye-densitometry. J Clin Monit 1997;13:81-89.
  • 19
    Kroon M, Groeneveld AB, Smulders YM. Cardiac output measurement by pulse dye densitometry: comparison with pulmonary artery thermodilution in post-cardiac surgery patients. J Clin Monit Comput 2005;19:395-399.
  • 20
    Levy BI, Ambrosio G, Pries AR, Struijker-Boudier HA. Microcirculation in hypertension: a new target for treatment?Circulation 2001;104:735-740.
  • 21
    DeLano FA, Schmid-Schonbein GW, Skalak TC, Zweifach BW. Penetration of the systemic blood pressure into the microvasculature of rat skeletal muscle. Microvasc Res 1991;41:92-110.
  • 22
    Serne EH, Gans RO, ter Maaten JC, ter Wee PM, Donker AJ, Stehouwer CD. Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions. Cardiovasc Res 2001;49:161-168.
  • 23
    Levy BI, Schiffrin EL, Mourad JJ, et al.Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus. Circulation 2008;118:968-976.
  • 24
    Noon JP, Walker BR, Webb DJ, et al.Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure. J Clin Invest 1997;99:1873-1879.
  • 25
    Agapitov AV, Correia ML, Sinkey CA, Dopp JM, Haynes WG. Impaired skeletal muscle and skin microcirculatory function in human obesity. J Hypertens 2002;20:1401-1405.
  • 26
    Serne EH, Stehouwer CD, ter Maaten JC, et al.Microvascular function relates to insulin sensitivity and blood pressure in normal subjects. Circulation 1999;99:896-902.
  • 27
    Lembo G, Iaccarino G, Vecchione C, Rendina V, Trimarco B. Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats. Hypertension 1995;26:290-293.
  • 28
    Jonk AM, Houben AJ, de Jongh RT, Serne EH, Schaper NC, Stehouwer CD. Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension. Physiology (Bethesda ) 2007;22:252-260.
  • 29
    Cardillo C, Campia U, Bryant MB, Panza JA. Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation 2002;106:1783-1787.
  • 30
    Cardillo C, Campia U, Iantorno M, Panza JA. Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients. Hypertension 2003;43:36-40.
  • 31
    Cardillo C, Nambi SS, Kilcoyne CM, et al.Insulin stimulates both endothelin and nitric oxide activity in the human forearm. Circulation 1999;100:820-825.
  • 32
    Noon JP, Walker BR, Hand MF, Webb DJ. Studies with iontophoretic administration of drugs to human dermal vessels in vivo: cholinergic vasodilatation is mediated by dilator prostanoids rather than nitric oxide. Br J Clin Pharmacol 1998;45:545-550.
  • 33
    Morris SJ, Shore AC. Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms. J Physiol 1996;496(Pt 2):531-542.
  • 34
    Khan F, Davidson NC, Littleford RC, Litchfield SJ, Struthers AD, Belch JJ. Cutaneous vascular responses to acetylcholine are mediated by a prostanoid-dependent mechanism in man. Vasc Med 1997;2:82-86.
  • 35
    Randin D, Vollenweider P, Tappy L, Jequier E, Nicod P, Scherrer U. Effects of adrenergic and cholinergic blockade on insulin-induced stimulation of calf blood flow in humans. Am J Physiol 1994;266(3 Pt 2):R809-R816.
  • 36
    Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 1991;87:2246-2252.
  • 37
    Hall JE, Brands MW, Zappe DH, et al.Hemodynamic and renal responses to chronic hyperinsulinemia in obese, insulin-resistant dogs. Hypertension 1995;25:994-1002.
  • 38
    Brands MW, Mizelle HL, Gaillard CA, Hildebrandt DA, Hall JE. The hemodynamic response to chronic hyperinsulinemia in conscious dogs. Am J Hypertens 1991;4(2 Pt 1):164-168.
  • 39
    Guyton AC. The relationship of cardiac output and arterial pressure control. Circulation 1981;64:1079-1088.
  • 40
    Baron AD, Brechtel-Hook G, Johnson A, Hardin D. Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure. Hypertension 1993;21:129-135.