Disclosure: Pia Christensen, Henning Bliddal, Birgit Falk Riecke, Marius Henriksen and Arne Astrup received travel grants to attend scientific meetings from the Cambridge Manufacturing Company.
Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults
Article first published online: 13 APR 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 10, pages 1982–1990, October 2013
How to Cite
Christensen, P., Frederiksen, R., Bliddal, H., Riecke, B. F., Bartels, E. M., Henriksen, M., Juul-S⊘rensen, T., Gudbergsen, H., Winther, K., Astrup, A. and Christensen, R. (2013), Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults. Obesity, 21: 1982–1990. doi: 10.1002/oby.20413
- Issue published online: 5 OCT 2013
- Article first published online: 13 APR 2013
- Accepted manuscript online: 20 MAR 2013 02:45AM EST
- Manuscript Accepted: 24 JAN 2013
- Manuscript Received: 30 AUG 2012
- The Oak Foundation
- The Velux Foundation
- The Cambridge Weight Plan
- The Danish Rheumatism Association
- The Augustinus Foundation
- The A.P. M⊘ller Foundation for the Advancement of Medical Science
- Erik H⊘rslev og hustru Birgit H⊘rslevs Fond
- Aase og Ejnar Danielsens fond and Bjarne Jensens Fond
Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk-factors, nutritional health, and body composition after 1-year weight-loss maintenance achieved by [D]diet, [E]knee-exercise, or [C]control, following weight loss by low-energy-diet.
Design and Methods
Obese individuals (n = 192, >50 years) with knee OA, 63 years (SD 6), weight 103.2 kg (15.0), body-mass index 37.3 kg/m2 (4.8), were enrolled into a 68-week weight-loss trial.
Mean changes in weight, in D, E, and C were −11.0, −6.3, and −8.3 kg (P = 0.002). Reduction in waist circumference in D, E, and C were −8.4, −4.6, and −7.0 cm (P = 0.007). D reduced waist circumference significantly more than E: −3.8 cm (95%CI −6.2 to −1.4; P = 0.0024). There was no difference between the groups in changes in CVD risk factors; blood pressure, triglycerides, and cholesterol. Nutritional health was improved in all groups. For markers of bone, no statistical difference was found between the groups.
Dietary support, or control, maintained improvements in cardiovascular risk factors to the same extent and none of the interventions had a detrimental effect on bone.