Disclosure: The authors declared no conflict of interest.
Probiotics L. plantarum and L. curvatus in Combination Alter Hepatic Lipid Metabolism and Suppress Diet-Induced Obesity
Article first published online: 11 JUN 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 12, pages 2571–2578, December 2013
How to Cite
Yoo, S.-R., Kim, Y.-J., Park, D.-Y., Jung, U.-J., Jeon, S.-M., Ahn, Y.-T., Huh, C.-S., McGregor, R. and Choi, M. S. (2013), Probiotics L. plantarum and L. curvatus in Combination Alter Hepatic Lipid Metabolism and Suppress Diet-Induced Obesity. Obesity, 21: 2571–2578. doi: 10.1002/oby.20428
- Issue published online: 3 DEC 2013
- Article first published online: 11 JUN 2013
- Accepted manuscript online: 20 MAR 2013 02:37AM EST
- Manuscript Accepted: 6 FEB 2013
- Manuscript Received: 12 MAR 2012
Objective: To determine the effects of naturally derived probiotic strains individually or combination on a short-term diet-induced obesity model.
Design and Methods: C57BL/6J mice (n = 50) were randomly divided into five groups, then fed a high-fat high-cholesterol diet (HFCD), HFCD and Lactobacillus plantarum KY1032 (PL, 1010cfu/day), HFCD and Lactobacillus curvatus HY7601 (CU, 1010cfu/day), HFCD and in combination with PL+CU (1010cfu/day), or a normal diet (ND) for 9 weeks.
Results: PL and CU showed distinct and shared metabolic activity against a panel of 50 carbohydrates. Fat accumulation in adipose tissue and liver was significantly reduced by probiotic strains CU or PL+CU. Probiotic strains CU or PL+CU reduced cholesterol in plasma and liver, while PL+CL had a synergistic effect on hepatic triglycerides. Probiotic strains PL+CU combination was more effective for inhibiting gene expressions of various fatty acid synthesis enzymes in the liver, concomitant with decreases in fatty acid oxidation-related enzyme activities and their gene expressions.
Conclusions: Multi-strain probiotics may prove more beneficial than single-strain probiotics to combat fat accumulation and metabolic alterations in diet-induced obesity.