Disclosure: The authors declare no conflicts of interest.
Relation of Food Intake Behaviors and Obesity Development in Young Common Marmoset Monkeys
Version of Record online: 2 JUL 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 9, pages 1891–1899, September 2013
How to Cite
Ross, C. N., Power, M. L., Artavia, J. M. and Tardif, S. D. (2013), Relation of Food Intake Behaviors and Obesity Development in Young Common Marmoset Monkeys. Obesity, 21: 1891–1899. doi: 10.1002/oby.20432
Funding agencies: This study was supported by a grant from NIH: R01 DK077639.
- Issue online: 23 SEP 2013
- Version of Record online: 2 JUL 2013
- Accepted manuscript online: 20 MAR 2013 02:34AM EST
- Manuscript Accepted: 13 FEB 2013
- Manuscript Received: 5 DEC 2012
- NIH. Grant Number: R01 DK077639
Objective: Increasing prevalence of childhood obesity and associated risks of adult type disease have led to worldwide concern. It remains unclear how genetic predisposition, environmental exposure to obesogenic food, and developmental programming interact to lead to overweight and obese children. The development of a nonhuman primate model of obesity, and particularly juvenile obesity, is an important step to elucidating the factors associated with obesity and evaluating intervention strategies.
Design and Methods: Infant marmosets were followed from birth to 12 months of age. Feeding phenotypes were determined through the use of behavioral observation, solid food intake trials, and liquid feeding trials monitored via lickometer.
Results: Marmosets found to be obese at 12 months of age (more than 14%body fat) start consuming solid food sooner and initiate more time off of care givers. These individuals developed stable feeding phenotypes that included being more efficient consumers during liquid intake trials, drinking more grams of diet per contact with the licksit.
Conclusions: The weaning process appears to be particularly important in the development of feeding phenotypes and the development of juvenile obesity for the marmosets, and thus this is the time that should be focused upon for intervention testing in both nonhuman primates and children.