Funding agencies: This study was supported by The Swedish Research Council, the Swedish Heart and Lung foundation, the Marianne and Marcus Wallenberg Foundation, EXODIAB, Dalarna University and Uppsala University.
Hypertriglyceridemic waist phenotype is associated with decreased insulin sensitivity and incident diabetes in elderly men
Article first published online: 13 JUN 2013
Copyright © 2013 The Obesity Society
Volume 22, Issue 2, pages 526–529, February 2014
How to Cite
Carlsson, A. C., Risérus, U. and Ärnlöv, J. (2014), Hypertriglyceridemic waist phenotype is associated with decreased insulin sensitivity and incident diabetes in elderly men. Obesity, 22: 526–529. doi: 10.1002/oby.20434
Disclosure: The authors declared no conflict of interest.
Author Contributions: JÄ and ACC conceived and designed the study; JÄ and ACC performed the statistical analysis; ACC, JÄ and UR interpreted the data; ACC drafted the manuscript; JÄ and UR critically revised the manuscript for important intellectual content; JÄ obtained the funding and supervised the study.
- Issue published online: 3 FEB 2014
- Article first published online: 13 JUN 2013
- Accepted manuscript online: 20 MAR 2013 02:33AM EST
- Manuscript Accepted: 17 FEB 2013
- Manuscript Received: 26 NOV 2012
- The Swedish Research Council
- Swedish Heart and Lung foundation
- Marianne and Marcus Wallenberg Foundation
- Dalarna University
- Uppsala University
Objective: To investigate the association between hypertriglyceridemic waist (HTGW) and insulin sensitivity (assessed by euglycemic clamp method), and the development of diabetes in a longitudinal community-based cohort of elderly men without diabetes at baseline.
Design and Methods: The present cross-sectional study comprised 1,026, 70-year-old men without diabetes. The gold standard euglycaemic–hyperinsulinaemic clamp technique was used. Six-year follow-up on diabetes status were available in n = 667. The HTGW phenotype was defined as having waist circumference ≥ 90 cm, and triglycerides ≥ 2 mmol L−1. The men were stratified into those having normal WC and TG (n = 299), one HTGW component (n = 606), and HTGW (n = 121).
Results: The association between insulin sensitivity and one HTGW component as well as HTGW was highly significant (P < 0.001) in the whole sample, as well as in individuals with high/low BMI (stratified at ≥25). In longitudinal analyses, participants with HTGW was associated with a more than fourfold increased risk for diabetes (Odds ratio 4.64, 95% CI 1.61–13.4, P = 0.004) compared to those with normal WC and TG.
Conclusion: The present study both confirm and extend previous research suggesting that the HTGW-phenotype portrays an increased glucometabolic risk, also in lean individuals.