Hypertriglyceridemic waist phenotype is associated with decreased insulin sensitivity and incident diabetes in elderly men

Authors

  • Axel C. Carlsson,

    1. Center for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
    2. Department of Public Health and Caring Sciences/Section of Geriatrics Uppsala University, Uppsala, Sweden
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  • Ulf Risérus,

    1. Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
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  • Johan Ärnlöv

    1. Department of Public Health and Caring Sciences/Section of Geriatrics Uppsala University, Uppsala, Sweden
    2. School of Health and Social Studies, Dalarna University, Falun, Sweden
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  • Funding agencies: This study was supported by The Swedish Research Council, the Swedish Heart and Lung foundation, the Marianne and Marcus Wallenberg Foundation, EXODIAB, Dalarna University and Uppsala University.

  • Disclosure: The authors declared no conflict of interest.

  • Author Contributions: JÄ and ACC conceived and designed the study; JÄ and ACC performed the statistical analysis; ACC, JÄ and UR interpreted the data; ACC drafted the manuscript; JÄ and UR critically revised the manuscript for important intellectual content; JÄ obtained the funding and supervised the study.

Correspondence: Carol A. Maher (axelcefam@hotmail.com)

Abstract

Objective: To investigate the association between hypertriglyceridemic waist (HTGW) and insulin sensitivity (assessed by euglycemic clamp method), and the development of diabetes in a longitudinal community-based cohort of elderly men without diabetes at baseline.

Design and Methods: The present cross-sectional study comprised 1,026, 70-year-old men without diabetes. The gold standard euglycaemic–hyperinsulinaemic clamp technique was used. Six-year follow-up on diabetes status were available in n = 667. The HTGW phenotype was defined as having waist circumference ≥ 90 cm, and triglycerides ≥ 2 mmol L−1. The men were stratified into those having normal WC and TG (n = 299), one HTGW component (n = 606), and HTGW (n = 121).

Results: The association between insulin sensitivity and one HTGW component as well as HTGW was highly significant (P < 0.001) in the whole sample, as well as in individuals with high/low BMI (stratified at ≥25). In longitudinal analyses, participants with HTGW was associated with a more than fourfold increased risk for diabetes (Odds ratio 4.64, 95% CI 1.61–13.4, P = 0.004) compared to those with normal WC and TG.

Conclusion: The present study both confirm and extend previous research suggesting that the HTGW-phenotype portrays an increased glucometabolic risk, also in lean individuals.

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