Disclosure: Dr. Havel and Dr. Stanhope have received travel funds and honoraria for presentations on the topic of the metabolic effects of sugar consumption at scientific conferences. They have also received honoraria for writing reviews on the topic of the metabolic effects of sugar consumption. Dr. Berglund receives consulting income from Danone Institute. The other authors have no disclosures or conflicts of interest to declare. Funding agencies: This research was supported with funding from NIH grant R01 HL-075675 and by CIHR (to KC). K. Cianflone holds a Canada Research Chair in Adipose Tissue. The project also received support from Grant Number UL1 RR024146 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Dr. Keim's research is supported by intramural USDA-ARS CRIS 5306-51530-016-00D. Dr. Havel has since received funding for further research on the metabolic effects of sugar consumption from NIH grants RO1 HL HL091333 and RO1 HL HL HL107256. Dr. Stanhope is supported by a Building Interdisciplinary Research Careers in Women's Health award (K12 HD051958) funded by the National Institute of Child Health and Human Development (NICHD), Office of Research on Women's Health (ORWH), Office of Dietary Supplements (ODS), and the National Institute of Aging (NIA).
Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin: Relationships with Metabolic Outcomes
Article first published online: 13 JUN 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 12, pages 2471–2480, December 2013
How to Cite
Rezvani, R., Cianflone, K., McGahan, J. P., Berglund, L., Bremer, A. A., Keim, N. L., Griffen, S. C., Havel, P. J. and Stanhope, K. L. (2013), Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin: Relationships with Metabolic Outcomes. Obesity, 21: 2471–2480. doi: 10.1002/oby.20437
- Issue published online: 3 DEC 2013
- Article first published online: 13 JUN 2013
- Accepted manuscript online: 20 MAR 2013 02:27AM EST
- Manuscript Accepted: 14 FEB 2013
- Manuscript Received: 18 JUN 2012
The effects of fructose and glucose consumption on plasma acylation stimulating protein (ASP), adiponectin, and leptin concentrations relative to energy intake, body weight, adiposity, circulating triglycerides, and insulin sensitivity were determined.
Design and Methods
Thirty two overweight/obese adults consumed glucose- or fructose-sweetened beverages (25% energy requirement) with their ad libitum diets for 8 weeks, followed by sweetened beverage consumption for 2 weeks with a standardized, energy-balanced diet. Plasma variables were measured at baseline, 2, 8, and 10 weeks, and body adiposity and insulin sensitivity at baseline and 10 weeks.
Fasting and postprandial ASP concentrations increased at 2 and/or 8 weeks. ASP increases correlated with changes in late-evening triglyceride concentrations. At 10 weeks, fasting adiponectin levels decreased in both groups, and decreases were inversely associated with baseline intra-abdominal fat volume. Sugar consumption increased fasting leptin concentrations; increases were associated with body weight changes. The 24-h leptin profiles increased during glucose consumption and decreased during fructose consumption. These changes correlated with changes of 24-h insulin levels.
The consumption of fructose and glucose beverages induced changes in plasma concentrations of ASP, adiponectin, and leptin. Further study is required to determine if these changes contribute to the metabolic dysfunction observed during fructose consumption.