B. Olsson and P.-A. Svensson contributed equally to this work.
Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity
Article first published online: 13 JUN 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 12, pages E571–E576, December 2013
How to Cite
Ahlin, S., Sjöholm, K., Jacobson, P., Andersson-Assarsson, J.C., Walley, A., Tordjman, J., Poitou, C., Prifti, E., Jansson, P.-A., Borén, J., Sjöström, L., Froguel, P., Bergman, R.N., Carlsson, L.M.S., Olsson, B. and Svensson, P.-A. (2013), Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of Obesity. Obesity, 21: E571–E576. doi: 10.1002/oby.20443
Disclosure: The authors declared no conflict of interest. B. Olsson and P.-A. Svensson contributed equally to this work.
- Issue published online: 3 DEC 2013
- Article first published online: 13 JUN 2013
- Accepted manuscript online: 20 MAR 2013 02:24AM EST
- Manuscript Accepted: 19 FEB 2013
- Manuscript Received: 6 JUL 2012
- Swedish Research Council. Grant Numbers: K2008-65X-20753-01-4, K2009-65X-15424-05-3, K2010-55X-11285-13
- Swedish Foundation for Strategic Research to Sahlgrenska Center for Cardiovascular and Metabolic Research
- Swedish Diabetes Foundation
- Åke Wiberg Foundation
- Foundations of the National Board of Health and Welfare
- Jeansson Foundations
- Magnus Bergvall Foundation
- Royal Physiographic Society (Nilsson-Ehle Foundation)
- Tore Nilsson Foundation
- Arosenius Foundation
- Clas Groschinsky Foundation
- Torsten and Ragnar Söderberg Foundation
- VINNOVA-VINNMER program
- Swedish federal government under the LUA/ALF agreement
- Wellcome Trust. Grant Number: GR079534)
- Hepadip consortium
- INSERM and the FLIP7th framework program
- Programme Hospitalier de Recherche Clinique
- Assistance Publique-Hôpitaux de Paris. Grant Number: AOR 02076
- Contrat de Recherche Clinique (CRIC to CP)
Objective: Obesity is linked to both increased metabolic disturbances and increased adipose tissue macrophage infiltration. However, whether macrophage infiltration directly influences human metabolism is unclear. The aim of this study was to investigate if there are obesity-independent links between adipose tissue macrophages and metabolic disturbances.
Design and Methods: Expression of macrophage markers in adipose tissue was analyzed by DNA microarrays in the SOS Sib Pair study and in patients with type 2 diabetes and a BMI-matched healthy control group.
Results: The expression of macrophage markers in adipose tissue was increased in obesity and associated with several metabolic and anthropometric measurements. After adjustment for BMI, the expression remained associated with insulin sensitivity, serum levels of insulin, C-peptide, high density lipoprotein cholesterol (HDL-cholesterol) and triglycerides. In addition, the expression of most macrophage markers was significantly increased in patients with type 2 diabetes compared to the control group.
Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. This indicates that adipose tissue macrophages may contribute to the development of insulin resistance and dyslipidemia.