Disclosure: All authors have read and approved the manuscript and none of them have any potential conflicts of interest to report.
Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression
Article first published online: 5 JUL 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 12, pages E626–E633, December 2013
How to Cite
Hoffmeister, A., Tuennemann, J., Sommerer, I., Mössner, J., Rittger, A., Schleinitz, D., Kratzsch, J., Rosendahl, J., Klöting, N., Stahl, T., Roßner, S., Paroni, F., Maedler, K., Kovacs, P. and Blüher, M. (2013), Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression. Obesity, 21: E626–E633. doi: 10.1002/oby.20482
Author contributions: A. H. provided research data and wrote manuscript, J. T.: research data, I. S.: research data, J. M. research data, A.R. provided Bace1–/– mice and research data, J. K. experimental data, J. R. provided samples for genetics studies, N. K. research data, T. S. research data, D. S. research data and genetics studies, S. R. wrote manuscript, F.P. research data, K.M. research data, P. K. performed genetics studies, M. B. research data and wrote manuscript.
Funding agencies: This work was supported by grants from the Federal Ministry of Education and Research, Competence Network Obesity (FKZ 01GI0829, FKZ: 01EO1001 to NK), Deutsche Forschungsgemeinschaft (RO 2226/10-1 to SR), the Clinical Research Group “Atherobesity” KFO 152 (projects BL 833/1-1 to MB, KO 3880/1-1 to PK and KL 2346 to NK), and by NIDDK and JDRF.
- Issue published online: 3 DEC 2013
- Article first published online: 5 JUL 2013
- Accepted manuscript online: 17 APR 2013 01:06PM EST
- Manuscript Accepted: 18 MAR 2013
- Manuscript Received: 16 JUL 2012