Funding agencies: This study was supported with funding from Ingredion Incorporated, the Louisiana State University Agricultural Center, and the Gordon Cain Professorship in the School of Human Ecology of the College of Agriculture of Louisiana State University.
Resistant starch from high amylose maize (HAM-RS2) and Dietary butyrate reduce abdominal fat by a different apparent mechanism
Article first published online: 15 OCT 2013
Copyright © 2013 The Obesity Society
Volume 22, Issue 2, pages 344–348, February 2014
How to Cite
Vidrine, K., Ye, J., Martin, R. J., McCutcheon, K. L., Raggio, A. M., Pelkman, C., Durham, H. A., Zhou, J., Senevirathne, R. N., Williams, C., Greenway, F., Finley, J., Gao, Z., Goldsmith, F. and Keenan, M. J. (2014), Resistant starch from high amylose maize (HAM-RS2) and Dietary butyrate reduce abdominal fat by a different apparent mechanism. Obesity, 22: 344–348. doi: 10.1002/oby.20501
Disclosure: Michael Keenan and Roy Martin have received funding from Ingredion Incorporated for research. Christine Pelkman is an employee of Ingredion Incorporated.
- Issue published online: 3 FEB 2014
- Article first published online: 15 OCT 2013
- Accepted manuscript online: 29 APR 2013 09:12AM EST
- Manuscript Accepted: 14 APR 2013
- Manuscript Received: 8 MAR 2013
Obesity is a health concern. Resistant starch (RS) type 2 from high-amylose maize (HAM-RS2) and dietary sodium butyrate (SB) reduce abdominal fat in rodents. RS treatment is associated with increased gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), but it is not known if SB increases these hormones.
Design and Methods
This was investigated in a 2 × 2 rat study with HAM-RS2 (0 or 28% weight) and dietary sodium butyrate (0 and 3.2%) resulting in isocaloric treatments: energy control (EC), sodium butyrate (SB), HAM-RS2 (RS), and the combination (SBRS).
RS and SB reduced abdominal fat and the combination reduced abdominal fat compared to SB and RS. RS was associated with increased fermentation in the cecum. Serum PYY and GLP-1 total were increased with RS treatment. RS treatment was associated with increased cecal butyrate produced from fermentation of RS, but there was no cecal increase for dietary SB.
SB after its absorption into the blood appears to not affect production of PYY and GLP-1, while butyrate from fermentation in the cecum promotes increased PYY and GLP-1. Future studies with lower doses of RS and SB are warranted and the combination may be beneficial for human health.