Funding agencies: Dr. Gokce is supported by National Institutes of Health (NIH) grants HL1145675, and HL084213. Dr. Farb is supported by an American Heart Association Postdoctoral Fellowship grant 12POST11780028. Dr. Walsh is supported by NIH grants HL068758 and AG034972. Dr. Vita is supported by NIH grants HL083801, HL083269, HL75795, and K12 HL083781. Dr. Hamburg is supported by NIH grants HL109790 and HL102299. Dr. Fetterman is supported by NIH grant T32 HL07224. Drs. Walsh, Gokce, and Vita are jointly supported by NIH grant P01 HL081587.
Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity
Version of Record online: 29 JUL 2013
Copyright © 2013 The Obesity Society
Volume 22, Issue 2, pages 349–355, February 2014
How to Cite
Farb, M. G., Tiwari, S., Karki, S., Ngo, D. T.M., Carmine, B., Hess, D. T., Zuriaga, M. A., Walsh, K., Fetterman, J. L., Hamburg, N. M., Vita, J. A., Apovian, C. M. and Gokce, N. (2014), Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity. Obesity, 22: 349–355. doi: 10.1002/oby.20505
Disclosure: The authors have no conflicts of interest with the current manuscript.
Author contributions: MGF conceived the study, performed all the vascular experiments, collected adipose samples during surgery, analyzed data, and prepared the manuscript. ST recruited and consented study subjects, and collected adipose samples during surgery. SK assisted with recruitment and in intellectual design. DTMN quantified prostanoids secretion from adipose tissue and assisted in data analysis. BC and DTH were involved in patient recruitment and provided clinical surgical specimens. MAZ and KW performed gene expression analyses and assisted with data analysis and interpretation. JLF assisted with analysis of data. NMH and JAV assisted with data interpretation, scientific direction, and manuscript preparation. CMA was involved in patient recruitment and assisted with intellectual design. NG conceived the overall experimental strategy and design, provided scientific direction, edited the manuscript, and oversaw all aspects of the experimental studies.
- Issue online: 3 FEB 2014
- Version of Record online: 29 JUL 2013
- Accepted manuscript online: 3 MAY 2013 03:49AM EST
- Manuscript Accepted: 24 APR 2013
- Manuscript Received: 21 DEC 2012
Additional Supporting Information may be found in the online version of this article.
|oby20505-sup-0001-suppfigs.doc||136K||Supplemental figure I: Ach-induced phosphorylation of eNOS at serine 1177 is impaired in endothelial cells isolated from visceral compared to subcutaneous depots. * p<0.05, n=7.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.