Trial Registration: The Pennington Center Longitudinal Study is registered at ClinicalTrials.gov (Identifier NCT00959270).
Brief Cutting Edge Report
Clinical utility and reproducibility of visceral adipose tissue measurements derived from dual-energy X-ray absorptiometry in white and African American adults
Version of Record online: 13 AUG 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 11, pages 2221–2224, November 2013
How to Cite
Katzmarzyk, P. T., Greenway, F. L., Heymsfield, S. B. and Bouchard, C. (2013), Clinical utility and reproducibility of visceral adipose tissue measurements derived from dual-energy X-ray absorptiometry in white and African American adults. Obesity, 21: 2221–2224. doi: 10.1002/oby.20519
Computed tomography and magnetic resonance imaging are currently used to measure abdominal visceral adipose tissue (VAT) in humans; however, more widely available and less costly dual-energy x-ray absorptiometry (DXA) also has the potential to measure VAT.
Disclosure: The authors have no competing interests.
- Issue online: 1 NOV 2013
- Version of Record online: 13 AUG 2013
- Accepted manuscript online: 21 JUN 2013 11:10PM EST
- Manuscript Accepted: 6 MAY 2013
- Manuscript Revised: 22 APR 2013
- Manuscript Received: 31 JAN 2013
The purpose of this study was to determine reproducibility and clinical thresholds for DXA-derived visceral adipose tissue (VAT).
Design and Methods
The sample included 2317 white and African American adults 18-74 years of age. VAT areas (cm2) were measured using a Hologic DXA scanner equipped with APEX 4.0 software. Reproducibility was assessed using repeated measurements on 101 participants scanned 14 days apart. Receiver Operating Characteristic (ROC) curves were used to assess clinical utility and select thresholds that identified elevated cardiometabolic risk, defined as the presence of ≥2 risk factors.
Reproducibility of DXA-VAT was 8.1%. The areas under the ROC curves ranged from 0.754 in African American men to 0.807 in white women. The thresholds were higher in white men (154 cm2) and women (143 cm2) compared to African American men (101 cm2) and women (114 cm2).
The results demonstrated that DXA VAT is a useful clinical marker of cardiometabolic risk; however, further research is required to determine associations with health outcomes using longitudinal studies.