Maki Goto and Atsushi Goto have contributed equally to this work.
Low-molecular-weight adiponectin and high-molecular-weight adiponectin levels in relation to diabetes
Version of Record online: 10 SEP 2013
Copyright © 2013 The Obesity Society
Volume 22, Issue 2, pages 401–407, February 2014
How to Cite
Goto, M., Goto, A., Morita, A., Deura, K., Sasaki, S., Aiba, N., Shimbo, T., Terauchi, Y., Miyachi, M., Noda, M., Watanabe, S. and for the Saku Cohort Study Group (2014), Low-molecular-weight adiponectin and high-molecular-weight adiponectin levels in relation to diabetes. Obesity, 22: 401–407. doi: 10.1002/oby.20553
Funding agencies: This work was supported in part by a grant from the Japan Diabetes Foundation.
Disclosure: The authors declare that there are no conflicts of interest.
Author contributions: MG and AG designed the study, conceived experiments, analyzed data, and wrote the manuscript. AM, KD, SS, NA, MM, and SW conducted the study and contributed to the discussion. TS contributed to the analysis and the discussion. YT, and MN contributed to the discussion, and reviewed/edited the manuscript. The authors acknowledge all members for their participation in this research and also thank Masanobu Ikeda and Tomoko Yasuda for their assistance.
- Issue online: 3 FEB 2014
- Version of Record online: 10 SEP 2013
- Accepted manuscript online: 1 JUL 2013 08:17AM EST
- Manuscript Accepted: 17 JUN 2013
- Manuscript Received: 12 MAR 2013
To evaluate the association between adiponectin complexes (high-molecular-weight [HMW], middle-molecular-weight [MMW], and low-molecular-weight [LMW] adiponectin) and diabetes.
Design and Methods
We conducted a case-control study, based on a cohort in Saku, Japan. Among 2565 participants, 300 participants with diabetes and 300 matched controls (430 men and 170 women) were analyzed.
After adjusting for age, physical activity, hypertension, family history, alcohol use, smoking, and menopausal status, total, HMW, and LMW, but not MMW adiponectin levels were inversely associated with diabetes: total adiponectin, odds ratio comparing the highest with the lowest quartiles, 0.46 (95% confidence interval, 0.25–0.82; P for trend = 0.046); HMW, 0.40 (95%CI, 0.22–0.72; P = 0.046); MMW, 1.04 (95%CI, 0.60–1.77; P = 0.81); and LMW, 0.51 (95%CI, 0.29–0.89; P = 0.01). The associations between total and HMW adiponectin and diabetes attenuated after adjustment for BMI (P = 0.15 and 0.13, respectively), but LMW remained (P = 0.04). When stratified by sex, LMW adiponectin levels were associated with diabetes in men only. None of the associations were significant after adjustment for HOMA-IR.
Decreased LMW, total, and HMW adiponectin levels are associated with diabetes. These associations may be secondary to adiposity or insulin resistance.