Disclosure: The authors report no conflict of interest
Methylphenidate decreases fat and carbohydrate intake in obese teenagers
Version of Record online: 3 DEC 2013
Copyright © 2013 The Obesity Society
Volume 22, Issue 3, pages 781–785, March 2014
How to Cite
Danilovich, N., Mastrandrea, L.D., Cataldi, L. and Quattrin, T. (2014), Methylphenidate decreases fat and carbohydrate intake in obese teenagers. Obesity, 22: 781–785. doi: 10.1002/oby.20574
Author Contributions: TQ designed the study and closely supervised the conduct of the study. ND carried out experiments and data collection. LC managed subject recruitment and data collection. ND, LDM, and TQ analyzed and interpreted data. All authors were involved in writing of the manuscript and had final approval of the submitted and published versions.
- Issue online: 5 MAR 2014
- Version of Record online: 3 DEC 2013
- Accepted manuscript online: 9 JUL 2013 09:16AM EST
- Manuscript Accepted: 25 JUN 2013
- Manuscript Received: 13 NOV 2012
Dopamine is a neurotransmitter that mediates the reward value of food. Methylphenidate (MPH) selectively binds and inhibits the dopamine transporter, thus increasing brain dopamine levels shortly after oral administration. This investigation studied whether a single dose of MPH decreases energy intake (EI) in obese teenagers compared to placebo (P).
This study used a single-blind, placebo-controlled, within subject design. Teenagers with body mass index (BMI) ≥95th percentile underwent two identical meal tests (P or MPH) after a 10 h fast in random order. Food was weighed before and after the meals, and EI was calculated as energy content/gram of consumed foods. Total and macronutrient EI (mean ± SD) were analyzed by Mann–Whitney U and Wilcoxon tests.
Twenty-two subjects (15 females, 7 males) completed the study. Participants were 13.4 ± 2.2 years old and had BMI 34.9 ± 10.7 kg/m². EI from fat (167 vs. 203 kcal, P = 0.03) and carbohydrates (311 vs. 389 kcal, P = 0.04) was decreased for MPH compared to P meals, with a trend in decreased total EI (545 vs. 663 kcal, P = 0.06).
A single dose of MPH decreases EI from fat and carbohydrates in obese adolescents. This effect underscores the importance of central dopamine signaling on eating behavior.