Funding agencies: This work was supported by an internationalization grant from the Swedish Council for Working Life and Social Research, EpiLife Center
Does change in hip circumference predict cardiovascular disease and overall mortality in Danish and Swedish women?
Article first published online: 20 SEP 2013
Copyright © 2013 The Obesity Society
How to Cite
Lanfer, A., Mehlig, K., Heitmann, B. L. and Lissner, L. (2013), Does change in hip circumference predict cardiovascular disease and overall mortality in Danish and Swedish women?. Obesity. doi: 10.1002/oby.20604
Disclosures: Nothing to report. Full financial disclosures and author notes may be found in the online version of this article.
- Article first published online: 20 SEP 2013
- Accepted manuscript online: 20 AUG 2013 10:57AM EST
- Manuscript Accepted: 12 AUG 2013
- Manuscript Received: 9 MAR 2013
Accumulating evidence consistently shows that small hip circumference (HC) is related to increased risk of cardiovascular disease (CVD), coronary heart disease, diabetes, and premature death in women. This study aims to clarify whether this inverse association can be found in both normal- and overweight individuals and if change in HC over time relates to morbidity and mortality risk.
Design and Methods
HC and 6-year change in HC in relation to the risk for all-cause mortality and CVD morbidity and mortality was investigated in a pooled sample of 2,867 women from the DANISH MONICA study and the Prospective Population Study of Women in Gothenburg with a total of 66,627 person-years of follow-up.
Baseline HC was significantly and inversely associated with all-cause and CVD-specific mortality after adjustment for BMI, waist circumference (WC), and other covariates. In stratified analyses, the inverse association was weaker in women with a BMI of more than 25 kg/m2. Six-year change in hip size was not associated with mortality or morbidity endpoints.
Our results imply the existence of a basal risk associated with small hip size, which is, however, independent from changes in gluteofemoral body mass and therefore unlikely to be modifiable.