Funding agencies: This work was funded by an Establishment Grant from Alberta Innovates–Health Solutions. Ms. A.A. Zalucky is supported by the Lung Association of Alberta and a Queen Elizabeth II Graduate Scholarship. Mr. D.D.M. Nicholl is supported by an American Society of Nephrology Studentship and the Jerry L. Weber Scholarship from the Cosmopolitan Club of Calgary. Ms. M.C. Mann is supported by a Canadian Institutes for Health Research doctoral scholarship. Drs. B.R. Hemmelgarn and S.B. Ahmed are supported by Alberta Innovates–Health Solutions and the Canadian Institute of Health Research.Disclosures: Drs. BR Hemmelgarn, JM MacRae and SB Ahmed are supported by a joint initiative between Alberta Health and Wellness and the Universities of Alberta and Calgary. Funding sources had no role in the design, conduct, or reporting of this study.
Sex influences the effect of body mass index on the vascular response to angiotensin II in humans
Article first published online: 20 SEP 2013
Copyright © 2013 The Obesity Society
Volume 22, Issue 3, pages 739–746, March 2014
How to Cite
Zalucky, A. A., Nicholl, D. D. M., Mann, M. C., Hemmelgarn, B. R., Turin, T. C., MacRae, J. M., Sola, D. Y. and Ahmed, S. B. (2014), Sex influences the effect of body mass index on the vascular response to angiotensin II in humans. Obesity, 22: 739–746. doi: 10.1002/oby.20608
- Issue published online: 5 MAR 2014
- Article first published online: 20 SEP 2013
- Accepted manuscript online: 20 AUG 2013 11:14AM EST
- Manuscript Accepted: 14 AUG 2013
- Manuscript Revised: 30 JUL 2013
- Manuscript Received: 22 APR 2013
Sex influences the cardiorenal risk associated with body mass index (BMI). The role of the renin–angiotensin–aldosterone system in adiposity-mediated cardiorenal risk profiles in healthy, non-obese men and women was investigated.
Systemic and renal hemodynamic responses to angiotensin-II (AngII) as a function of BMI, waist and hip circumference, waist–hip ratio, as well as fat and lean mass were measured in 18 men and 25 women in high-salt balance, stratified by BMI (<25 kg/m2 (ideal body weight (IBW)) vs. ≥25 kg/m2 overweight)).
In men (n = 7, BMI 23 ± 1 kg/m2) and women (n = 14, BMI 22 ± 2 kg/m2) of IBW, BMI was not associated with the systolic blood pressure (SBP) response to AngII. In contrast, overweight men (n = 11, 29 ± 2 kg/m2) demonstrated a progressively more blunted vasoconstrictor SBP response to AngII challenge as BMI increased (P = 0.007), even after adjustment for covariates. Women maintained the same relationship between BMI and the SBP response to AngII irrespective of weight status (P = 0.2, IBW vs. overweight women). Compared to BMI, other adiposity measures showed similar associations to systemic AngII responsiveness in men but not in women. Increasing BMI was associated with a blunted renovasoconstrictor response to AngII in all subjects, but was more pronounced in men.
Sex influences the effect of adiposity on vascular angiotensin-responsiveness.