Disclosure: The authors declare no conflict of interest.
Modifying effect of obesity on the association between sitting and incident diabetes in post-menopausal women
Article first published online: 4 DEC 2013
Copyright © 2013 The Obesity Society
Volume 22, Issue 4, pages 1133–1141, April 2014
How to Cite
Manini, T. M., LaMonte, M. J., Seguin, R. A., Manson, J. E., Hingle, M., Garcia, L., Stefanick, M. L., Rodriguez, B., Sims, S., Song, Y. and Limacher, M. (2014), Modifying effect of obesity on the association between sitting and incident diabetes in post-menopausal women. Obesity, 22: 1133–1141. doi: 10.1002/oby.20620
Author contributions: TMM led the writing team; TMM conducted analysis under direction of ML; all authors contributed substantively to the interpretation of the results and development, editing, and/or writing of the manuscript.
- Issue published online: 26 MAR 2014
- Article first published online: 4 DEC 2013
- Accepted manuscript online: 30 SEP 2013 09:15AM EST
- Manuscript Accepted: 6 SEP 2013
- Manuscript Received: 31 MAY 2013
To evaluate the association between self-reported daily sitting time and the incidence of type 2 diabetes in a cohort of postmenopausal women.
Women (N=88,829) without diagnosed diabetes reported the number of hours spent sitting over a typical day. Incident cases of diabetes were identified annually by self-reported initiation of using oral medications or insulin for diabetes > 14.4 years follow-up.
Each hour of sitting time was positively associated with increased risk of diabetes [risk ratio (RR): 1.05; 95% confidence interval (CI): 1.02–1.08]. However, sitting time was only positively associated with incident diabetes in obese women. Obese women reporting sitting 8–11 (RR: 1.08; 95% CI 1.0–1.1), 12–15 (OR: 1.13; 95% CI 1.0–1.2), and ≥16 hours (OR: 1.25; 95% CI 1.0–1.5) hours per day had an increased risk of diabetes compared to women sitting ≤7 hours per day. These associations were adjusted for demographics, health conditions, behaviors (smoking, diet, and alcohol intake), and family history of diabetes. Time performing moderate to vigorous intensity physical activity did not modify these associations.
Time spent sitting was independently associated with increased risk of diabetes diagnosis among obese women—a population already at high risk of the disease.