Funding agencies: This research was supported by a Proof of Principle award from The Novo Nordisk Diabetes Innovation Award Program (to AAB), and R01 DK060412 and 2P30 DK072476 (NORC) (ER). MPSO acknowledges the support of National Institutes of Health grants #1R01HL091352-01A1, 1R01HL091352-01S1, 1 UL1 RR024156-03, and P30 DK-26687.
Fasting plasma adropin concentrations correlate with fat consumption in human females
Article first published online: 16 OCT 2013
Copyright © 2013 The Obesity Society
Volume 22, Issue 4, pages 1056–1063, April 2014
How to Cite
St-Onge, M.-P., Shechter, A., Shlisky, J., Tam, C. S., Gao, S., Ravussin, E. and Butler, A. A. (2014), Fasting plasma adropin concentrations correlate with fat consumption in human females. Obesity, 22: 1056–1063. doi: 10.1002/oby.20631
Disclosure: The authors have no competing interests.
Author Contributions: MPSO and AAB conceived the experiment, performed the analysis and wrote/reviewed/edited the manuscript. AR, JS, SG, and NHR contributed to data collection. CST performed some of the assays, analyzed data and contributed to manuscript preparation. JS and SG reviewed the manuscript. ER participated in study design, discussions of data interpretation and provided materials. AAB coordinated activity between research sites and had the primary responsibility for writing the manuscript.
- Issue published online: 26 MAR 2014
- Article first published online: 16 OCT 2013
- Accepted manuscript online: 1 OCT 2013 05:17AM EST
- Manuscript Accepted: 16 SEP 2013
- Manuscript Received: 20 JUN 2013
This study investigated whether plasma adropin concentrations are influenced by sleep restriction and correlate with dietary preferences.
Plasma adropin concentrations were measured by ELISA using samples from a study that investigated feeding behavior in sleep deprived lean (body mass index 22-26 kg/m2) men and women aged 30-45 y. Sleep (habitual or restricted to 4h/night) and diet were controlled during a 4-day inpatient period. On day 5, food was self-selected (FS). Adropin was measured on day 4 in samples collected throughout the day, and then after an overnight fast at 0730 on days 5 (Pre-FS) and 6 (Post-FS).
Plasma adropin concentrations were not affected by sleep restriction. However, circulating adropin concentrations correlated with food selection preferences in women, irrespective of sleep status. Pre-FS adropin correlated positively with fat intake (total fat, r = 0.867, P < 0.05; saturated fat, r = 0.959, P < 0.01) and negatively with carbohydrate intake (r = -0.894, P < 0.05) as a percent total energy. Post-FS adropin correlated with total (r = 0.797, P < 0.05) and saturated fat intake (r = 0.945, P < 0.01), and negative with total carbohydrate intake (r = -0.929, P < 0.01). Pre-FS adropin also correlated with fat intake in kcal adjusted for body size (total fat, r = 0.852, P < 0.05; saturated fat, r = 0.927, P < 0.01).
Plasma adropin concentrations correlate with fat consumption in women.