Associations of maternal pre-pregnancy and gestational body size with offspring longitudinal change in BMI

Authors

  • Gabriella M. Lawrence,

    Corresponding author
    1. Braun School of Public Health, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
    Search for more papers by this author
  • Shani Shulman,

    1. Braun School of Public Health, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
    Search for more papers by this author
  • Yechiel Friedlander,

    1. Braun School of Public Health, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
    Search for more papers by this author
  • Colleen M. Sitlani,

    1. Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    2. Departments of Medicine, University of Washington, Seattle, Washington, USA
    3. Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Search for more papers by this author
  • Ayala Burger,

    1. Braun School of Public Health, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
    Search for more papers by this author
  • Bella Savitsky,

    1. Braun School of Public Health, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
    Search for more papers by this author
  • Einat Granot-Hershkovitz,

    1. Braun School of Public Health, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
    Search for more papers by this author
  • Thomas Lumley,

    1. Department of Biostatistics, University of Washington, Seattle, Washington, USA
    2. Department of Statistics, University of Auckland, Auckland, New Zealand
    Search for more papers by this author
  • Pui-Yan Kwok,

    1. Institute for Human Genetics, Cardiovascular Research Institute and Department of Dermatology, University of California, San Francisco, California, USA
    Search for more papers by this author
  • Stephanie Hesselson,

    1. Institute for Human Genetics, Cardiovascular Research Institute and Department of Dermatology, University of California, San Francisco, California, USA
    Search for more papers by this author
  • Daniel Enquobahrie,

    1. Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    2. Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Search for more papers by this author
  • Pandora L. Wander,

    1. Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    2. Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Search for more papers by this author
  • Orly Manor,

    1. Braun School of Public Health, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
    Search for more papers by this author
  • David S. Siscovick,

    1. Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    2. Departments of Medicine, University of Washington, Seattle, Washington, USA
    3. Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Search for more papers by this author
  • Hagit Hochner

    1. Braun School of Public Health, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel
    Search for more papers by this author

  • Funding agencies: This research was supported by the NIH research grant R01HL088884 and the Israeli Science Foundation grant No. 1252/07.

  • Disclosure: The authors declare no conflict of interest.

  • Author contributions: All authors were involved in writing the paper and had final approval of the submitted version.

Abstract

Objectives

Studies demonstrate associations between changes in obesity-related phenotypes and cardiovascular risk. Although maternal pre-pregnancy BMI (mppBMI) and gestational weight gain (GWG) may be associated with adult offspring adiposity, no study has examined associations with obesity changes. Associations of mppBMI and GWG with longitudinal change in offspring's BMI (ΔBMI) were examined, and whether associations are explained by offspring genetics was assessed.

Methods

A birth cohort of 1400 adults, with data at birth, age 17 and 32 years was used. After genotyping offspring, genetic scores, predictive of exposures and outcome were created, and linear regression models with and without scores were fit to examine the associations of mppBMI and GWG with ΔBMI.

Results

A one SD change in mppBMI and GWG was associated with a 0.83 and a 0.75 kg/m² increase in ΔBMI, respectively. The association between mppBMI and offspring ΔBMI was slightly attenuated (12%) with the addition of genetic scores. In the GWG model, a significant substantial 28.2% decrease in the coefficient was observed.

Conclusions

This study points to an association between maternal excess weight in pregnancy and offspring BMI change from adolescence to adulthood. Genetic factors may account, in part, for GWG/ΔBMI association. These findings broaden observations that maternal obesity-related phenotypes have long-term consequences for offspring health.

Ancillary