Funding agencies: This research was supported by the NIH research grant R01HL088884 and the Israeli Science Foundation grant No. 1252/07.
Associations of maternal pre-pregnancy and gestational body size with offspring longitudinal change in BMI
Article first published online: 5 DEC 2013
Copyright © 2013 The Obesity Society
Volume 22, Issue 4, pages 1165–1171, April 2014
How to Cite
Lawrence, G. M., Shulman, S., Friedlander, Y., Sitlani, C. M., Burger, A., Savitsky, B., Granot-Hershkovitz, E., Lumley, T., Kwok, P.-Y., Hesselson, S., Enquobahrie, D., Wander, P. L., Manor, O., Siscovick, D. S. and Hochner, H. (2014), Associations of maternal pre-pregnancy and gestational body size with offspring longitudinal change in BMI. Obesity, 22: 1165–1171. doi: 10.1002/oby.20643
Disclosure: The authors declare no conflict of interest.
Author contributions: All authors were involved in writing the paper and had final approval of the submitted version.
- Issue published online: 26 MAR 2014
- Article first published online: 5 DEC 2013
- Accepted manuscript online: 12 OCT 2013 11:11AM EST
- Manuscript Accepted: 6 OCT 2013
- Manuscript Received: 15 APR 2013
Studies demonstrate associations between changes in obesity-related phenotypes and cardiovascular risk. Although maternal pre-pregnancy BMI (mppBMI) and gestational weight gain (GWG) may be associated with adult offspring adiposity, no study has examined associations with obesity changes. Associations of mppBMI and GWG with longitudinal change in offspring's BMI (ΔBMI) were examined, and whether associations are explained by offspring genetics was assessed.
A birth cohort of 1400 adults, with data at birth, age 17 and 32 years was used. After genotyping offspring, genetic scores, predictive of exposures and outcome were created, and linear regression models with and without scores were fit to examine the associations of mppBMI and GWG with ΔBMI.
A one SD change in mppBMI and GWG was associated with a 0.83 and a 0.75 kg/m² increase in ΔBMI, respectively. The association between mppBMI and offspring ΔBMI was slightly attenuated (12%) with the addition of genetic scores. In the GWG model, a significant substantial 28.2% decrease in the coefficient was observed.
This study points to an association between maternal excess weight in pregnancy and offspring BMI change from adolescence to adulthood. Genetic factors may account, in part, for GWG/ΔBMI association. These findings broaden observations that maternal obesity-related phenotypes have long-term consequences for offspring health.