Funding agencies: This research was supported by the Scientific Foundation board of the Royal College of General Practitioners (RCGP), grant number SFB 2013-28, and a European Hydration Institute (EHI) Student Research Grant.
Efficacy of water preloading before main meals as a strategy for weight loss in primary care patients with obesity: RCT
Version of Record online: 3 AUG 2015
© 2015 The Obesity Society
Volume 23, Issue 9, pages 1785–1791, September 2015
How to Cite
Parretti, H. M., Aveyard, P., Blannin, A., Clifford, S. J., Coleman, S. J., Roalfe, A. and Daley, A. J. (2015), Efficacy of water preloading before main meals as a strategy for weight loss in primary care patients with obesity: RCT. Obesity, 23: 1785–1791. doi: 10.1002/oby.21167
Disclosure: The authors declare no conflict of interest.
Author contributions: AJD conceived the original idea for the study. HMP, AJD, and PA designed the study. HMP, AJD, and PA drafted the paper with additional input from AB, AR, SJCl, and SJCo. HMP and AR conducted the statistical analyses, and HMP, AJD, and PA wrote the results. AB conducted the urine analyses. SJCl was responsible for data collation and management. SJCo was responsible for data collection and collation. All authors have read and agreed to the final version of the manuscript.
Clinical trial registration: ISRCTN33238158.
- Issue online: 26 AUG 2015
- Version of Record online: 3 AUG 2015
- Manuscript Accepted: 1 MAY 2015
- Manuscript Revised: 29 APR 2015
- Manuscript Received: 11 NOV 2014
- The Scientific Foundation board of the Royal College of General Practitioners. Grant Number: SFB 2013-28
To investigate the efficacy of water preloading before meals as a weight loss strategy for adults with obesity.
A two-group randomized controlled trial was conducted in Birmingham, England. Eighty-four adults with obesity were recruited from general practices. All participants were given a face-to-face weight management consultation at baseline (30 min) and a follow-up telephone consultation at 2 weeks (10 min). At baseline, participants were randomized to either drinking 500 ml of water 30 min before their main meals or an attention control group where participants were asked to imagine their stomach was full before meals. The primary outcome was weight change at 12-week follow-up. Several measures of adherence were also used, including 24 h total urine collections.
41 participants were randomized to the intervention group and 43 to the comparator group. The water preloading group lost −1.3 kg (95% CI −2.4 to −0.1, P = 0.028) more than comparators at follow up. Adjusting for ethnicity, deprivation, age, and gender resulted in the intervention group losing −1.2 kg (95% CI −2.4 to 0.07, P = 0.063) more than the comparator.
There is preliminary evidence that water preloading before main meals leads to a moderate weight loss at follow up. ISRCTN33238158