See Commentary, pg. 792.
Effects of a mindfulness-based weight loss intervention in adults with obesity: A randomized clinical trial
Version of Record online: 9 MAR 2016
© 2016 The Authors. Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS)
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Volume 24, Issue 4, pages 794–804, April 2016
How to Cite
Daubenmier, J., Moran, P. J., Kristeller, J., Acree, M., Bacchetti, P., Kemeny, M. E., Dallman, M., Lustig, R. H., Grunfeld, C., Nixon, D. F., Milush, J. M., Goldman, V., Laraia, B., Laugero, K. D., Woodhouse, L., Epel, E. S. and Hecht, F. M. (2016), Effects of a mindfulness-based weight loss intervention in adults with obesity: A randomized clinical trial. Obesity, 24: 794–804. doi: 10.1002/oby.21396
Funding agencies: This study was supported by NIH grants from the National Center for Complementary and Alternative Medicine (NCCAM) P01AT005013 (Hecht), K24AT007827 (Hecht), and K01AT004199 (Daubenmier), as well as the National Center for Advancing Translational Sciences, UCSF-CTSI Grant Number UL1 TR000004.
Disclosure: Dr. Kristeller participated in a paid webinar on “mindful snacking” for Allidura Consumer; the other authors declared no conflict of interest.
Author contributions: JD, PM JK, PB, MD, RL, CG, DN, MK, BL, EE, and FH conceived of and designed the study. JD, EE, and FH obtained funding. JD, PM, MA, PB, JM, VG, KL, LW, EE, and FH acquired the data. JD, PM, JK, MA, PB, MD, BL, CG, DN, JM, MK, BL, EE, and FH analyzed and interpreted the data. JD, PM, EE, and FH drafted the manuscript. All authors were involved in writing the paper and had final approval of the submitted and published versions.
Clinical trial registration: ClinicalTrials.gov identifier NCT00960414.
Elissa S. Epel and Frederick M. Hecht contributed equally as co-senior authors.
- Issue online: 30 MAR 2016
- Version of Record online: 9 MAR 2016
- Manuscript Accepted: 5 OCT 2015
- Manuscript Revised: 1 OCT 2015
- Manuscript Received: 21 MAY 2015
To determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components.
In this study 194 adults with obesity were randomized to a 5.5-month program with or without mindfulness training and identical diet-exercise guidelines. Intention-to-treat analyses with multiple imputation were used for missing data. The primary outcome was 18-month weight change.
Estimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, −1.9 kg (95% CI: −4.5, 0.8; P = 0.17), and 18 months, −1.7 kg (95% CI: −4.7, 1.2; P = 0.24), though not statistically significant; (b) changes in fasting glucose at 12 months, −3.1 mg/dl (95% CI: −6.3, 0.1; P = 0.06), and 18 months, −4.1 mg/dl (95% CI: −7.3, −0.9; P = 0.01); and (c) changes in triglyceride/HDL ratio at 12 months, −0.57 (95% CI: −0.95, −0.18; P = 0.004), and 18 months, −0.36 (95% CI: −0.74, 0.03; P = 0.07). Estimates for other metabolic risk factors were not statistically significant, including waist circumference, blood pressure, and C-reactive protein.
Mindfulness enhancements to a diet-exercise program did not show substantial weight loss benefit but may promote long-term improvement in some aspects of metabolic health in obesity that requires further study.