• Open Access

A Platform for Specific Delivery of Lanthanide–Scandium Mixed-Metal Cluster Fullerenes into Target Cells

Authors

  • Anna Svitova,

    1. Department of Electrochemistry and Conducting Polymers, Leibniz Institute of Solid State and Material Research, Helmholtzstrasse 20, 01069 Dresden (Germany)
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  • Dr. Klaus Braun,

    Corresponding author
    1. Department of Medical Physics in Radiology, German Cancer Research Center, INF 280, 69120 Heidelberg (Germany)
    • Department of Medical Physics in Radiology, German Cancer Research Center, INF 280, 69120 Heidelberg (Germany)
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  • Dr. Alexey A. Popov,

    1. Department of Electrochemistry and Conducting Polymers, Leibniz Institute of Solid State and Material Research, Helmholtzstrasse 20, 01069 Dresden (Germany)
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  • Prof. Dr. Lothar Dunsch

    Corresponding author
    1. Department of Electrochemistry and Conducting Polymers, Leibniz Institute of Solid State and Material Research, Helmholtzstrasse 20, 01069 Dresden (Germany)
    • Department of Electrochemistry and Conducting Polymers, Leibniz Institute of Solid State and Material Research, Helmholtzstrasse 20, 01069 Dresden (Germany)
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Abstract

original image

A shuttle into cells: A modular c-myc-antisense-Gd@BioShuttle system (see figure), comprising a gadolinium- containing nitride cluster fullerene as an imaging component, an address module (nuclear localization sequence) and a transmembrane carrier peptide, is prepared, and its facile intracellular localization is proven by in vitro studies.

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