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Keywords:

  • cycloaddition reactions;
  • homogeneous catalyses;
  • polycyclic compounds;
  • rearrangements;
  • sequential catalyses
Thumbnail image of graphical abstract

Cascade transformation: A highly regioselective and stereoselective synthesis of polyfunctional indoles from isatin derivatives and allenic esters is disclosed. The novel cascade transformation is a direct and rapid entry to polycyclic indoles through sequential catalysis of rearrangement and [4+2] cycloaddition under very mild conditions bearing various substituents at many positions.