Rapid Microfluidic Immunoassays of Cancer Biomarker Proteins Using Disposable Inkjet-Printed Gold Nanoparticle Arrays
Article first published online: 12 JUN 2013
© 2013 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Volume 2, Issue 4, pages 141–145, August 2013
How to Cite
Krause, C. E., Otieno, B. A., Latus, A., Faria, R. C., Patel, V., Gutkind, J. S. and Rusling, J. F. (2013), Rapid Microfluidic Immunoassays of Cancer Biomarker Proteins Using Disposable Inkjet-Printed Gold Nanoparticle Arrays. ChemistryOpen, 2: 141–145. doi: 10.1002/open.201300018
- Issue published online: 26 AUG 2013
- Article first published online: 12 JUN 2013
- Manuscript Received: 16 APR 2013
- Funded Access
- National Institute of Biomedical Imaging and Bioengineering (NIBIB)
- US National Institutes of Health (NIH). Grant Number: EB014586
- Intramural Research Program, National Institute of Dental and Craniofacial Research (NIDCR), NIH
- cancer biomarkers;
- inkjet-printed arrays;
Off-line amplification: A low-cost inkjet-printed gold nanoparticle immunoarray was integrated into a microfluidic device for multiple protein determinations. The use of heavily labeled magnetic beads allows optimization either for ultrasensitive detection of biomarker proteins (low fg mL−1 levels) or for rapid 8 min assays within clinically relevant detection ranges.