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Keywords:

  • bioinorganic chemistry;
  • enzyme inhibitors;
  • organometallic compounds;
  • protein structures;
  • ruthenium
Thumbnail image of graphical abstract

Non-hinge binding: A novel organometallic protein kinase inhibitor scaffold based on a cyclometalated 1,8-phenanthrolin-7(8 H)-one ligand is reported, which binds to the ATP binding site of the protein kinase Pim1 in an unexpected, unusual non-ATP-mimetic fashion without mimicking the hydrogen-bonding interaction of the adenine nucleobase of ATP.