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ChemistryOpen

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February 2012

Volume 1, Issue 1

Pages 1–56

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. Editorial
    6. Masthead
    7. News
    8. Communications
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      Cover Picture: (ChemistryOpen 1/2012) (page 1)

      Article first published online: 28 FEB 2012 | DOI: 10.1002/open.201290001

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      The cover picture shows the concept behind ChemistryOpen. By creating the first chemical society-owned open-access journal, ChemPubSoc Europe and Wiley-VCH have unlocked the door to all areas of chemistry, symbolized here by the periodic table. Work published in ChemistryOpen will be accessible to all, irrespective of socioeconomic or geographical considerations. With the backing of 16 continental European chemical societies and the experience of its sister journals to hand, ChemistryOpen is expected to continue the high standards and level of excellence to be expected from a ChemPubSoc Europe journal.

  2. Masthead

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      Masthead: ChemistryOpen 1/2012 (page 2)

      Article first published online: 28 FEB 2012 | DOI: 10.1002/open.201290002

  3. Graphical Abstract

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      Graphical Abstract: ChemistryOpen 1/2012 (pages 3–8)

      Article first published online: 28 FEB 2012 | DOI: 10.1002/open.201290003

  4. Editorial

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      Opening Up the World of Chemistry (page 4)

      Ramón Martínez-Máñez and Thomas Wirth

      Article first published online: 2 JAN 2012 | DOI: 10.1002/open.201100009

  5. Masthead

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      Masthead: ChemistryOpen 1/2012 (page 9)

      Article first published online: 28 FEB 2012 | DOI: 10.1002/open.201290004

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      Spotlights on our sister journals: ChemistryOpen 1/2012 (pages 10–12)

      Article first published online: 28 FEB 2012 | DOI: 10.1002/open.201290000

  7. Communications

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      Determining the Role of the Aromatic Ring of N-Arylmethyl ent-conduramine F-1 in their Interactions with α-Glucosidases by Saturation Transfer Difference NMR Spectroscopy Experiments (pages 13–16)

      Dr. Antonio Hernández Daranas, Sonia Koteich Khatib, Dr. Robert Lysek, Dr. Pierre Vogel and Dr. José A. Gavín

      Article first published online: 2 JAN 2012 | DOI: 10.1002/open.201100004

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      Saturation transfer difference (STD) NMR spectroscopy was used to study the role of aromatic moieties in the inhibition of α-glucosidases by N-arylmethyl ent-conduramine F-1. STD epitope mapping and molecular docking simulations provide new insights into the structure-based design of drugs targeting this enzyme (see figure).

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      Dual Enzyme-Triggered Controlled Release on Capped Nanometric Silica Mesoporous Supports (pages 17–20)

      Alessandro Agostini, Dr. Laura Mondragón, Dr. Carmen Coll, Dr. Elena Aznar, Dr. M. Dolores Marcos, Prof. Ramón Martínez-Máñez, Dr. Félix Sancenón, Dr. Juan Soto, Prof. Enrique Pérez-Payá and Prof. Pedro Amorós

      Article first published online: 17 FEB 2012 | DOI: 10.1002/open.201200003

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      Please release me: Mesoporous silica nanoparticles capped with bulky organic moieties containing amide and urea linkages were able to release their cargo upon addition of amidase and urease. Amidase induced an immediate, yet not complete, release of the cargo. On the other hand, urease allowed a near total cargo release that was delayed in time (see graph).

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      Through-Hole, Self-Ordered Nanoporous Oxide Layers on Titanium, Niobium and Titanium–Niobium Alloys in Aqueous and Organic Nitrate Electrolytes (pages 21–25)

      Robin Kirchgeorg, Wei Wei, Kiyoung Lee, Seugli So and Prof. Dr. Patrik Schmuki

      Article first published online: 10 FEB 2012 | DOI: 10.1002/open.201100012

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      Leaky layers: Several 10 μm-thick, highly aligned, porous structures of titanium dioxide, niobium pentoxide and mixed oxides can be grown anodically in nitrate-containing electrolytes with channel diameters in the range of 10–20 nm. Depending on the substrate, the electrochemical growth parameters need to be optimized to achieve a high degree of long-range order.

  8. Full Papers

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      Semi-Synthesis and Analysis of Chemically Modified Zif268 Zinc-Finger Domains (pages 26–32)

      Dr. Friederike Fehr, Dr. André Nadler, Dr. Florian Brodhun, Prof. Dr. Ivo Feussner and Prof. Dr. Ulf Diederichsen

      Article first published online: 2 JAN 2012 | DOI: 10.1002/open.201100002

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      The entire zinc-finger domain of Zif268 was synthesized by a semi-synthetic pathway using the expressed protein ligation approach. Despite several modifications, for example, attachment of a fluorophore and introduction of a metal-chelating amino acid within the sequence of the third zinc finger, circular dichroism spectroscopic measurements confirmed zinc-induced folding and intact DNA binding ability.

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      High Cytotoxic Activity of Phosphonium Salts and Their Complementary Selectivity towards HeLa and K562 Cancer Cells: Identification of Tri-n-butyl-n-hexadecylphosphonium bromide as a Highly Potent Anti-HeLa Phosphonium Salt (pages 33–38)

      Dr. Barbara Bachowska, Julia Kazmierczak-Baranska, Dr. Marcin Cieslak, Prof. Barbara Nawrot, Dorota Szczęsna, Joanna Skalik and Prof. Piotr Bałczewski

      Article first published online: 17 FEB 2012 | DOI: 10.1002/open.201100003

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      Complementary toxicity: Phosphonium salts with halogen anions are several times more cytotoxic against HeLa and K562 cancer cells than the clinically used reference compound cisplatin and show unusual complementary anticancer selectivity, which has not previously been reported in the literature.

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      Characterization of Microwave-Induced Electric Discharge Phenomena in Metal–Solvent Mixtures (pages 39–48)

      Wen Chen, Bernhard Gutmann and Prof. Dr. C. Oliver Kappe

      Article first published online: 10 FEB 2012 | DOI: 10.1002/open.201100013

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      Turning on the power: Irradiating metal–solvent mixtures with microwaves produces electric discharges that are critically dependent on microwave power, solvent, metal type, size and morphology.

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      Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β,α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids (pages 49–56)

      Alejandro Trejos, Dr. Luke R. Odell and Prof. Mats Larhed

      Article first published online: 28 FEB 2012 | DOI: 10.1002/open.201100010

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      Watch out for water! The stereoselective diarylation of three different metal-coordinating, cyclic methylamino vinyl ethers is described. The reaction proceeds via a chelation-controlled Heck/Suzuki diarylation pathway, and represents the first example of a stereoselective, oxidative Heck/Suzuki domino reaction.

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