Dual Enzyme-Triggered Controlled Release on Capped Nanometric Silica Mesoporous Supports (pages 17–20)
Alessandro Agostini, Dr. Laura Mondragón, Dr. Carmen Coll, Dr. Elena Aznar, Dr. M. Dolores Marcos, Prof. Ramón Martínez-Máñez, Dr. Félix Sancenón, Dr. Juan Soto, Prof. Enrique Pérez-Payá and Prof. Pedro Amorós
Article first published online: 17 FEB 2012 | DOI: 10.1002/open.201200003
Please release me: Mesoporous silica nanoparticles capped with bulky organic moieties containing amide and urea linkages were able to release their cargo upon addition of amidase and urease. Amidase induced an immediate, yet not complete, release of the cargo. On the other hand, urease allowed a near total cargo release that was delayed in time (see graph).