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ChemistryOpen

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October 2012

Volume 1, Issue 5

Pages 197–231

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. News
    6. Masthead
    7. Communications
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      Cover Picture: (ChemistryOpen 5/2012) (page 197)

      Article first published online: 17 OCT 2012 | DOI: 10.1002/open.201290020

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      The cover picture shows the concept behind ChemistryOpen. By creating the first chemical society-owned open-access journal, ChemPubSoc Europe and Wiley-VCH have unlocked the door to all areas of chemistry, symbolized here by the periodic table. Work published in ChemistryOpen will be accessible to all, irrespective of socioeconomic or geographical considerations. With the backing of 16 continental European chemical societies and the experience of its sister journals to hand, ChemistryOpen is expected to continue the high standards and level of excellence to be expected from a ChemPubSoc Europe journal.

  2. Masthead

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. News
    6. Masthead
    7. Communications
    1. You have full text access to this OnlineOpen article
      Masthead: ChemistryOpen 5/2012 (page 198)

      Article first published online: 17 OCT 2012 | DOI: 10.1002/open.201290021

  3. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. News
    6. Masthead
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    1. You have full text access to this OnlineOpen article
      Graphical Abstract: ChemistryOpen 5/2012 (pages 199–201)

      Article first published online: 17 OCT 2012 | DOI: 10.1002/open.201290022

  4. News

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. News
    6. Masthead
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    1. You have full text access to this OnlineOpen article
      Spotlights on our sister journals: ChemistryOpen 5/2012 (pages 202–205)

      Article first published online: 17 OCT 2012 | DOI: 10.1002/open.201290023

  5. Masthead

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. News
    6. Masthead
    7. Communications
    1. You have full text access to this OnlineOpen article
      Masthead: ChemistryOpen 5/2012 (page 206)

      Article first published online: 17 OCT 2012 | DOI: 10.1002/open.201290024

  6. Communications

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Graphical Abstract
    5. News
    6. Masthead
    7. Communications
    1. You have full text access to this OnlineOpen article
      A Platform for Specific Delivery of Lanthanide–Scandium Mixed-Metal Cluster Fullerenes into Target Cells (pages 207–210)

      Anna Svitova, Dr. Klaus Braun, Dr. Alexey A. Popov and Prof. Dr. Lothar Dunsch

      Article first published online: 28 SEP 2012 | DOI: 10.1002/open.201200023

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      A shuttle into cells: A modular c-myc-antisense-Gd@BioShuttle system (see figure), comprising a gadolinium- containing nitride cluster fullerene as an imaging component, an address module (nuclear localization sequence) and a transmembrane carrier peptide, is prepared, and its facile intracellular localization is proven by in vitro studies.

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      Highly Defined, Colloid-Like Ionic Clusters in Solution (pages 211–214)

      Dennis Kurzbach, Dr. Daniel R. Kattnig, Nane Pfaffenberger, Dr. Wolfgang Schärtl and Dr. Dariush Hinderberger

      Article first published online: 5 SEP 2012 | DOI: 10.1002/open.201200025

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      Ionoids: Macrocyclic, organic and small inorganic building blocks electrostatically self-assemble in solution. The formed nano-objects feature a mobile interior. The molecules inside the aggregates seem to rotate freely on certain spatial positions. The hydrodynamic radius of the nano-assemblies, however, is precisely defined.

    3. You have full text access to this OnlineOpen article
      Highly Stereoselective Synthesis of Polycyclic Indoles through Rearrangement/[4+2] Cycloaddition under Sequential Catalysis (pages 215–220)

      Di-Han Zhang and Prof. Min Shi

      Article first published online: 11 SEP 2012 | DOI: 10.1002/open.201200028

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      Cascade transformation: A highly regioselective and stereoselective synthesis of polyfunctional indoles from isatin derivatives and allenic esters is disclosed. The novel cascade transformation is a direct and rapid entry to polycyclic indoles through sequential catalysis of rearrangement and [4+2] cycloaddition under very mild conditions bearing various substituents at many positions.

    4. You have full text access to this OnlineOpen article
      Cation versus Radical: Studies on the C/O Regioselectivity in Electrophilic Tri-, Di- and Monofluoromethylations of β-Ketoesters (pages 221–226)

      Yu-Dong Yang, Xu Lu, Guokai Liu, Etsuko Tokunaga, Dr. Seiji Tsuzuki and Prof. Norio Shibata

      Article first published online: 11 OCT 2012 | DOI: 10.1002/open.201200032

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      Fluoromethylation. The C/O regioselectivity of β-ketoesters with fluorinated methylsulfoxinium salts 2 is discussed. Trifluoromethylation involves the formation of a more cationic species represented by +CF3 to provide C-alkylated products, while monofluoromethylation possibly proceeds involving a more radical-like species such as .CFH2 to give O-alkylated species. Difluoromethylation could involve both cationic and radical species, which afford a mixture of C and O isomers.

    5. You have full text access to this OnlineOpen article
      Efficient Difluoromethylation of sp3 Carbon Nucleophiles by Bromodifluoromethylation Reagents with Organic Bases (pages 227–231)

      Guokai Liu, Xin Wang, Dr. Xu Lu, Xiu-Hua Xu, Etsuko Tokunaga and Prof. Norio Shibata

      Article first published online: 11 OCT 2012 | DOI: 10.1002/open.201200033

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      Bromodifluoromethylation reagents 1 can be used during electrophilic difluoromethylation for sp3 carbon nucleophiles mediated by organic bases. Allylic difluoromethylation of dicyanoalkylidens proceeds nicely by 1 in the presence of P1 base to give CF2H instead of CF2Br products in high to excellent yields. A wide range of β-ketoesters are also efficiently reacted with 1, mediated by DBU to provide C[BOND]CF2H compounds as major products with a small amount of O[BOND]CF2H products in high to excellent yields.

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