Antibody-Capped Mesoporous Nanoscopic Materials: Design of a Probe for the Selective Chromo-Fluorogenic Detection of Finasteride (pages 251–259)
Dr. Estela Climent, Prof. Ramón Martínez-Máñez, Prof. Ángel Maquieira, Dr. Félix Sancenón, Dr. M. Dolores Marcos, Dr. Eva M. Brun, Dr. Juan Soto and Prof. Pedro Amorós
Article first published online: 24 OCT 2012 | DOI: 10.1002/open.201100008
Antibodies as gatekeepers: Novel capped mesoporous silica nanoparticles (MSN) using antibodies as gatekeepers have been prepared in order to detect finasteride. In the presence of these particles (S1-AB), displacement of the antibody takes place, uncapping the pores and releasing the entrapped dye (see figure). Detection of finasteride in biological samples was tested using blank urine as standard matrix.