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ChemistryOpen

Cover image for Vol. 2 Issue 2

April 2013

Volume 2, Issue 2

Pages 39–75

  1. Cover Picture

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    5. Masthead
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      Cover Picture: Metal-Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes (ChemistryOpen 2/2013) (page 39)

      Dr. Thomas Reiner, Dominik Jantke, Dr. Alexander N. Marziale, Andreas Raba and Prof. Jörg Eppinger

      Version of Record online: 23 APR 2013 | DOI: 10.1002/open.201390005

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      The cover picture illustrates the concept of using metal-conjugated affinity labels (m-ALs) to convert proteases into well-defined and catalytically active artificial metalloenzymes. The X-ray structure of the papain-bound inhibitor E64c (orange) served as the basis to predict the orientation of the half-sandwich rhodium(III) moiety (yellow sphere) within the binding pocket of the protease. The well-defined position of the affinity label on the protein surface leads to a distinct environment of the metal center, which translates into enantiomeric ratios of up to 82:18 in the aqueous hydrogenation of ketones. For more details, see the Communication by Jörg Eppinger et al., on p. 50 ff.

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      Metal-Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes (page 40)

      Dr. Thomas Reiner, Dominik Jantke, Dr. Alexander N. Marziale, Andreas Raba and Prof. Jörg Eppinger

      Version of Record online: 23 APR 2013 | DOI: 10.1002/open.201300015

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      We reasoned that covalent approaches so far suffered from an ill-defined orientation of the metal center on the protein surface. Using specifically designed metal-conjugated affinity labels to introduce metal centers into the binding pocket of cysteine proteases, we generate a structurally distinct binding mode of the cofactor.” This and more about the story behind the cover research can be found on p. 50.

  3. Graphical Abstract

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      Graphical Abstract: ChemistryOpen 2/2013 (pages 41–44)

      Version of Record online: 23 APR 2013 | DOI: 10.1002/open.201390006

  4. Masthead

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      Masthead: ChemistryOpen 2/2013 (page 42)

      Version of Record online: 23 APR 2013 | DOI: 10.1002/open.201390007

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      Masthead: ChemistryOpen 2/2013 (page 45)

      Version of Record online: 23 APR 2013 | DOI: 10.1002/open.201390008

  5. News

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  6. Communications

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    1. You have full text access to this OnlineOpen article
      Metal-Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes (pages 50–54)

      Dr. Thomas Reiner, Dominik Jantke, Dr. Alexander N. Marziale, Andreas Raba and Prof. Jörg Eppinger

      Version of Record online: 20 FEB 2013 | DOI: 10.1002/open.201200044

      Thumbnail image of graphical abstract

      How to train a protein: Metal-conjugated affinity labels were used to selectively position catalytically active metal centers in the binding pocket of proteases. The resulting artificial metalloenzymes achieve up to 82 % e.r. in the hydrogenation of ketones. The modular setup enables a rapid generation of artificial metalloenzyme libraries, which can be adapted to a broad range of catalytic conditions.

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      Self-Organizing Surface-Initiated Polymerization of Multicomponent Photosystems: Stack Exchange with Fullerenes (pages 55–57)

      Dr. Altan Bolag, Dr. Hironobu Hayashi, Pierre Charbonnaz, Dr. Naomi Sakai and Prof. Stefan Matile

      Version of Record online: 19 MAR 2013 | DOI: 10.1002/open.201300004

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      Like beads on a string: A synthetic method for the directional construction of strings of spherical fullerenes along stacks of planar oligothiophenes is described. The key to success was the preparation of fullerenes with two solubilizing tri(ethylene glycol) tails (bold) and an aromatic aldehyde for covalent capture by hydrazides along the oligothiophene stacks (red).

    3. You have full text access to this OnlineOpen article
      An Instantaneous and Highly Selective Chromofluorogenic Chemodosimeter for Fluoride Anion Detection in Pure Water (pages 58–62)

      Sameh Elsayed, Alessandro Agostini, Luis E. Santos-Figueroa, Prof. Ramón Martínez-Máñez and Dr. Félix Sancenón

      Version of Record online: 3 APR 2013 | DOI: 10.1002/open.201300010

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      The fast and the fluoride: A pyridine derivative functionalized with tert-butyldimethylsilyl ether has been synthesized and used as a selective chromofluorogenic fluoride sensor in water/cetyltrimethylammonium bromide solutions. The chromofluorogenic response arises from the fluoride-induced hydrolysis of the silyl ether moiety, which generates a coloured and highly emissive phenolate anion.

  7. Full Papers

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    1. You have full text access to this OnlineOpen article
      Ruthenium-Catalyzed Intramolecular [2+2+2] Cycloaddition and Tandem Cross-Metathesis of Triynes and Enediynes (pages 63–68)

      Wei Yuan, Dr. Yin Wei and Prof. Dr. Min Shi

      Version of Record online: 19 FEB 2013 | DOI: 10.1002/open.201300002

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      Back to generation one! Catalyzed by the first-generation Grubbs ruthenium complex, intramolecular [2+2+2] cycloaddition of triynes to their benzene derivatives 2 and tandem cross-metathesis reactions of enediynes to their conjugated triene derivatives 4 perform smoothly in moderate to good yields under mild conditions. A possible reaction mechanism is presented on the basis of deuterium-labeling results.

    2. You have full text access to this OnlineOpen article
      Get More Out of Your Data: A New Approach to Agglomeration and Aggregation Studies Using Nanoparticle Impact Experiments (pages 69–75)

      Joanna Ellison, Dr. Kristina Tschulik, Emma J. E. Stuart, Dr. Kerstin Jurkschat, Dr. Dario Omanović, Dr. Margitta Uhlemann, Dr. Alison Crossley and Prof. Dr. Richard G. Compton

      Version of Record online: 15 MAR 2013 | DOI: 10.1002/open.201300005

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      The impact of Ag nanoparticles: A new approach to both sizing nanoparticles in solution and determining their agglomeration and aggregation state solely by electrochemical methods is presented. The data obtained by this method is critically compared to results of nanoparticle tracking analysis.

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