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ChemistryOpen

Cover image for Vol. 3 Issue 2

April 2014

Volume 3, Issue 2

Pages 37–75

  1. Cover Pictures

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    4. Graphical Abstract
    5. Masthead
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      Cover Picture: Conformational Dynamics of DNA G-Quadruplex in Solution Studied by Kinetic Capillary Electrophoresis Coupled On-line with Mass Spectrometry (ChemistryOpen 2/2014) (page 37)

      Gleb G. Mironov, Dr. Victor Okhonin, Dr. Nasrin Khan, Dr. Christopher M. Clouthier and Prof. Dr. Maxim V. Berezovski

      Version of Record online: 19 APR 2014 | DOI: 10.1002/open.201480201

      Thumbnail image of graphical abstract

      The cover picture shows two-dimensional separation of unfolded (green) and folded (red) forms of G-quadruplex DNA. The first dimension is kinetic capillary electrophoresis (KCE) separation of unfolded and folded DNA with different potassium ion concentrations in solution. The second dimension is ion mobility mass spectrometry separation of DNA conformers in the gas phase. The picture further shows DNA folding into a compact G-quadruplex structure, which is mediated by potassium ions. For more details, see the Full Paper by Maxim V. Berezovski and co-workers, on p. 58 ff.

  2. Cover Profiles

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      Conformational Dynamics of DNA G-Quadruplex in Solution Studied by Kinetic Capillary Electrophoresis Coupled On-line with Mass Spectrometry (page 38)

      Gleb G. Mironov, Dr. Victor Okhonin, Dr. Nasrin Khan, Dr. Christopher M. Clouthier and Prof. Dr. Maxim V. Berezovski

      Version of Record online: 10 APR 2014 | DOI: 10.1002/open.201400004

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      We did not expect such a big difference in migration time between folded and unfolded DNA. Our initial guess was that we could measure only a thermodynamic folding constant, but not rate constants for the fast conformational change.” More about the story behind the cover research can be found on p. 58.

  3. Graphical Abstract

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  4. Masthead

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      Masthead: ChemistryOpen 2/2014 (page 40)

      Version of Record online: 19 APR 2014 | DOI: 10.1002/open.201480221

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      Masthead: ChemistryOpen 2/2014 (page 43)

      Version of Record online: 19 APR 2014 | DOI: 10.1002/open.201480222

  5. News

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  6. Communications

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    1. You have full text access to this OnlineOpen article
      Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis (pages 48–53)

      Dr. Brian M. Zeglis, Fabien Emmetiere, Dr. Nagavarakishore Pillarsetty, Prof. Ralph Weissleder, Prof. Jason S. Lewis and Prof. Thomas Reiner

      Version of Record online: 6 APR 2014 | DOI: 10.1002/open.201402000

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      The earlier, the better! We report a novel synthesis of tetrazine-functionalized artificial amino acids, the creation of a model tetrazine-containing pentapeptide using solid-phase peptide synthesis, and the facile and rapid bioorthogonal radiolabeling of this peptide using a 89Zr-desferrioxamine-labeled trans-cyclooctene.

    2. You have full text access to this OnlineOpen article
      Room Temperature, Metal-Free Arylation of Aliphatic Alcohols (pages 54–57)

      Dr. Raju Ghosh, Erik Lindstedt, Dr. Nazli Jalalian and Prof. Berit Olofsson

      Version of Record online: 11 APR 2014 | DOI: 10.1002/open.201402006

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      Easy, quick and green! Diaryliodonium salts are demonstrated as efficient arylating agents of aliphatic alcohols under mild and metal-free conditions. The reaction proceeds at room temperature within 90 min to give alkyl aryl ethers in good to excellent yields.

  7. Full Papers

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    5. Masthead
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    1. You have full text access to this OnlineOpen article
      Conformational Dynamics of DNA G-Quadruplex in Solution Studied by Kinetic Capillary Electrophoresis Coupled On-line with Mass Spectrometry (pages 58–64)

      Gleb G. Mironov, Dr. Victor Okhonin, Dr. Nasrin Khan, Dr. Christopher M. Clouthier and Prof. Dr. Maxim V. Berezovski

      Version of Record online: 2 APR 2014 | DOI: 10.1002/open.201400002

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      Combining forces! Kinetic capillary electrophoresis is coupled on-line with mass spectrometry (KCE-MS) to study conformational dynamics of DNA G-quadruplexes in solution. Peak's shift and its widening in KCE help measure rate and equilibrium constants; and ion mobility spectrometry (IMS) provides relative sizes, absolute molecular masses and stoichiometry.

    2. You have full text access to this OnlineOpen article
      N-Aryl Isoleucine Derivatives as Angiotensin II AT2 Receptor Ligands (pages 65–75)

      Dr. Malte Behrends, Dr. Charlotta Wallinder, Dr. Anna Wieckowska, Dr. Marie-Odile Guimond, Prof. Anders Hallberg, Prof. Nicole Gallo-Payet and Prof. Mats Larhed

      Version of Record online: 13 MAR 2014 | DOI: 10.1002/open.201300040

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      Human not pig receptors! A series of benzamide substituted N-aryl isoleucine derivatives targeting the human AT2R have been synthesized. In this series, ligands with Ki values down to the single digit micromolar range have been identified. The presented data emphasize the importance of using human receptors in drug discovery programs.

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