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ChemistryOpen

Cover image for Vol. 3 Issue 3

June 2014

Volume 3, Issue 3

Pages 77–123

  1. Cover Pictures

    1. Top of page
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    3. Cover Profiles
    4. Graphical Abstract
    5. Masthead
    6. News
    7. Thesis Treasury
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      Cover Picture: Synthesis and Photochromic Properties of Configurationally Varied Azobenzene Glycosides (ChemistryOpen 3/2014) (page 77)

      Dr. Vijayanand Chandrasekaran, Eugen Johannes, Hauke Kobarg, Prof. Dr. Frank D. Sönnichsen and Prof. Thisbe K. Lindhorst

      Version of Record online: 18 JUN 2014 | DOI: 10.1002/open.201480301

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      The cover picture shows the principal structures of the azobenzene glycosides, which were synthesized in our work using glycosylation for preparation of the 1,2-trans glycosides and Mills reaction for azobenzene coupling (as indicated by the retrosynthetic pair of scissors). Irradiation of these glycoconjugates effects E[RIGHTWARDS ARROW]Z isomerization of the azobenzene N=N double bond, thus causing a significant change of the relative spatial orientation of the conjugated sugar moiety. The photochromic properties of these ‘sweet switches’ were investigated to allow their later employment in spatiotemporal manipulation of cellular interactions, in particular bacterial adhesion to surfaces, which is carbohydrate specific. Effects of the anomeric configuration as well as configuration at the 2-position of the sugar ring, and in addition, the effect of ortho-substitution of the azobenzene aglycone were systematically studied. Interestingly, all three factors influence the photochromic properties of azobenzene glycosides including drastic structure-specific concentration effects. For more details, see the Full Paper by Thisbe K. Lindhorst and co-workers, on 10.1002/open.201402010 (p. 99 ff.)

  2. Cover Profiles

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    4. Graphical Abstract
    5. Masthead
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      Synthesis and Photochromic Properties of Configurationally Varied Azobenzene Glycosides (page 78)

      Dr. Vijayanand Chandrasekaran, Eugen Johannes, Hauke Kobarg, Prof. Dr. Frank D. Sönnichsen and Prof. Thisbe K. Lindhorst

      Version of Record online: 18 JUN 2014 | DOI: 10.1002/open.201402016

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      We were very much surprised to see the extreme concentration dependencies of photoswitching of the ortho-carboxy-substituted azobenzene glycosides. This finding requires further detailed spectroscopic and theoretical studies.” More about the story behind the cover research can be found on 10.1002/open.201402016 (p. 78.)

  3. Graphical Abstract

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    2. Cover Pictures
    3. Cover Profiles
    4. Graphical Abstract
    5. Masthead
    6. News
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  4. Masthead

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      Masthead: ChemistryOpen 3/2014 (page 80)

      Version of Record online: 18 JUN 2014 | DOI: 10.1002/open.201480321

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      Masthead: ChemistryOpen 3/2014 (page 83)

      Version of Record online: 18 JUN 2014 | DOI: 10.1002/open.201480322

  5. News

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    5. Masthead
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  6. Thesis Treasury

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    1. You have full text access to this OnlineOpen article
      Corroles: Synthesis, Functionalization and Application as Chemosensors (pages 88–92)

      Carla I. M. Santos

      Version of Record online: 11 APR 2014 | DOI: 10.1002/open.201402001

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      Corroles exhibit rich spectroscopic features such as high molar extinction coefficients and fluorescence quantum yields. The core can accommodate various metal ions, which can act as active centers, and the periphery can be functionalized to enhance binding specificity. This work focusses on the synthesis of meso-triarylcorroles and their functionalization for use as fluorescent chemosensors of anions and metals.

  7. Full Papers

    1. Top of page
    2. Cover Pictures
    3. Cover Profiles
    4. Graphical Abstract
    5. Masthead
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    1. You have full text access to this OnlineOpen article
      Highly Efficient and Stereoselective Construction of Bispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction (pages 93–98)

      Dr. Qin Xu, De Wang, Dr. Yin Wei and Prof. Dr. Min Shi

      Version of Record online: 18 JUN 2014 | DOI: 10.1002/open.201402003

      Thumbnail image of graphical abstract

      Three compounds, one reaction! A highly regio- and stereoselective synthesis of bispirooxindoles by 1,3-dipolar cycloaddition of in situ generated azomethine ylides from isatin and proline to different electron-deficient alkenes has been developed, affording desired bispiro scaffold compounds in excellent yields.

    2. You have full text access to this OnlineOpen article
      Synthesis and Photochromic Properties of Configurationally Varied Azobenzene Glycosides (pages 99–108)

      Dr. Vijayanand Chandrasekaran, Eugen Johannes, Hauke Kobarg, Prof. Dr. Frank D. Sönnichsen and Prof. Thisbe K. Lindhorst

      Version of Record online: 18 JUN 2014 | DOI: 10.1002/open.201402010

      Thumbnail image of graphical abstract

      Sweet switches: Azobenzene glycosides with systematically varied structural properties were synthesized using glycoside synthesis and Mills reaction. Their photochromic properties were tested to evaluate their usefulness in studies requiring temporal and spatial alteration of carbohydrate orientation.

    3. You have full text access to this OnlineOpen article
      An Improved Rapid Mixing Device for Time-Resolved Electrospray Mass Spectrometry Measurements (pages 109–114)

      Nicholas Zinck, Dr. Ann-Kathrin Stark, Dr. Derek J. Wilson and Dr. Michal Sharon

      Version of Record online: 16 JUN 2014 | DOI: 10.1002/open.201402002

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      In the flow! The development of an improved continuous-flow mixing apparatus for real-time electrospray mass spectrometry measurements is described. The performance of the device is demonstrated by monitoring the unfolding reaction of cytochrome C, yielding improved signal-to-noise ratio and reduced experimental repeat errors.

    4. You have full text access to this OnlineOpen article
      Magnetic Resonance Access to Transiently Formed Protein Complexes (pages 115–123)

      Tomáš Sára, Thomas C. Schwarz, Dr. Dennis Kurzbach, Christoph H. Wunderlich, Prof. Christoph Kreutz and Prof. Robert Konrat

      Version of Record online: 18 JUN 2014 | DOI: 10.1002/open.201402008

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      Observing the unobserved: Low-affinity protein–protein complexes of transiently interacting proteins are hallmarks of signaling cascades and of great relevance in biology. We show how novel NMR and EPR techniques can be used for characterizing weak protein–protein complexes and their potential to study hitherto unobserved higher-order structures of proteins.

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