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Computational model for adaptive fiber-strengthened endothelial cell layers under flow induced shear-stress

  1. M. H. Buschmann1,*,
  2. H. J. Schnittler2,†,
  3. N. A. Adams1,‡

Article first published online: 22 DEC 2004

DOI: 10.1002/pamm.200410260

Issue

PAMM

PAMM

Volume 4, Issue 1, pages 558–559, December 2004

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How to Cite

Buschmann, M. H., Schnittler, H. J. and Adams, N. A. (2004), Computational model for adaptive fiber-strengthened endothelial cell layers under flow induced shear-stress. Proc. Appl. Math. Mech., 4: 558–559. doi: 10.1002/pamm.200410260

Author Information

  1. 1

    Institut für Strömungsmechanik, Technische Universität Dresden

  2. 2

    Institut für Physiologie, Medizinisch Theoretisches Zentrum, Technische Universität Dresden

  1. †

    Phone: +49 351 458 6007, Fax: +49 351 458 6301

  2. ‡

    Phone: +49 351 463 37607, Fax: +49 351 463 35246

*Phone: +49 351 463 36649, Fax: +49 351 463 35246

Publication History

  1. Issue published online: 22 DEC 2004
  2. Article first published online: 22 DEC 2004

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Abstract

Endothelial cells, covering the inner surface of human vessels and the heart are permanently exposed to fluid shear stress which strongly affects endothelial structure and function. Due to their location at the interface between blood-flow and the vascular wall endothelial cells play an essential role in hemodynamics. We present a complex computational model based on the Navier-Stokes equations, Donell's shell equations, and additional constitutive systems of equations for the description of the flow around and inside of endothelial cells. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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