A pH-sensitive water-soluble N-carboxyethyl chitosan/poly(hydroxyethyl methacrylate) hydrogel as a potential drug sustained release matrix prepared by photopolymerization technique

Authors

  • Yingshan Zhou,

    1. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
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  • Dongzhi Yang,

    1. State Key Laboratory of Chemical Resource Engineering and College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China
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  • Guiping Ma,

    1. State Key Laboratory of Chemical Resource Engineering and College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China
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  • Hailin Tan,

    1. State Key Laboratory of Chemical Resource Engineering and College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China
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  • Yu Jin,

    1. State Key Laboratory of Chemical Resource Engineering and College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China
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  • Jun Nie

    Corresponding author
    1. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
    2. State Key Laboratory of Chemical Resource Engineering and College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China
    • Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
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Abstract

Biocompatible pH-sensitive semi-interpenetration polymeric network hydrogels (semi-IPN) based on water-soluble N-carboxyethyl chitosan (CECS) and 2-hydroxyethyl methacrylate (HEMA) were synthesized by the photopolymerization technique. pH-sensitivity, cytotoxicity, morphology, mechanical property, and water state of hydrogel were investigated by a swelling test, methylthiazolydiphenyl-tetrazolium bromide (MTT) assay, scanning electron microscopy (SEM), universal testing machine, and differential scanning calorimetry (DSC), respectively. The drug release studies were carried out using 5-Flurouracil as the model drug. The results indicated that the hydrogels were sensitive to pH of the medium and its wet state had good mechanical properties. The results of cytotoxicity and prolonged drug release characteristics revealed the suitability of the hydrogels as drug delivery matrices. The release kinetics was evaluated by fitting the experimental data to standard release equations, and the best fit was obtained with the Higuchi model of the hydrogel. Copyright © 2008 John Wiley & Sons, Ltd.

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