• 1
    Serini G, Gabbiani G. Mechanisms of myofibroblast activity and phenotypic modulation. Exp Cell Res 1999; 250: 273283.
  • 2
    Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002; 3: 349363.
  • 3
    Desmoulière A, Redard M, Darby I, Gabbiani G. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 1995; 146: 5666.
  • 4
    Gabbiani G, Ryan GB, Majno G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 1971; 27: 549550.
  • 5
    Darby I, Skalli O, Gabbiani G. α-Smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 1990; 63: 2129.
  • 6
    Dugina V, Fontao L, Chaponnier C, Vasiliev J, Gabbiani G. Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors. J Cell Sci 2001; 114: 32853296.
  • 7
    Gabbiani G, Le Lous M, Bailey AJ, Bazin S, Delaunay A. Collagen and myofibroblasts of granulation tissue: a chemical, ultrastructural and immunologic study. Virchows Archiv B Cell Pathol 1976; 21: 133145.
  • 8
    Borsi L, Castellani P, Risso AM, Leprini A, Zardi L. Transforming growth factor-beta regulates the splicing pattern of fibronectin messenger RNA precursor. FEBS Lett 1990; 261: 175178.
  • 9
    Serini G, Bochaton-Piallat ML, Ropraz P, et al. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-β1. J Cell Biol 1998; 142: 873881.
  • 10
    Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993; 122: 103111.
  • 11
    Ronnov-Jessen L, Petersen OW. Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts: implications for myofibroblast generation in breast neoplasia. Lab Invest 1993; 68: 696707.
  • 12
    Roberts AB, Sporn MB, Assoian RK, et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986; 83: 41674171.
  • 13
    Xia P, Culp LA. Adhesion activity in fibronectin's alternatively spliced domain ED-A (EIIIA) and its neighboring type III repeats: oncogene-dependent regulation. Exp Cell Res 1994; 213: 253265.
  • 14
    Chi-Rosso G, Gotwals PJ, Yang J, et al. Fibronectin type III repeats mediate RGD-independent adhesion and signaling through activated beta1 integrins. J Biol Chem 1997; 272: 31 44731 452.
  • 15
    Moyano JV, Carnemolla B, Dominguez-Jimenez C, et al. Fibronectin type III5 repeat contains a novel cell adhesion sequence, KLDAPT, which binds activated alpha4beta1 and alpha4beta7 integrins. J Biol Chem 1997; 272: 24 83224 836.
  • 16
    Moyano JV, Carnemolla B, Albar JP, et al. Cooperative role for activated alpha4beta1 integrin and chondroitin sulfate proteoglycans in cell adhesion to be heparin III domain of fibronectin. Identification of a novel heparin and cell binding sequence in repeat III5. J Biol Chem 1999; 274: 135142.
  • 17
    Hocking DC, Sottile J, McKeown-Longo PJ. Activation of distinct alpha5beta1-mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domains. J Cell Biol 1998; 141: 241253.
  • 18
    Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G. A monoclonal antibody against α-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986; 103: 27872796.
  • 19
    Chaponnier C, Goethals M, Janmey PA, Gabbiani F, Gabbiani G, Vandekerckhove J. The specific NH2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo. J Cell Biol 1995; 130: 887895.
  • 20
    Hinz B, Gabbiani G, Chaponnier C. The NH2-terminal peptide of α-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo. J Cell Biol 2002; 157: 657663.