Astrocyte intermediate filaments in CNS pathologies and regeneration
Article first published online: 19 OCT 2004
Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: The Cytoskeleton and Disease
Volume 204, Issue 4, pages 428–437, November 2004
How to Cite
Pekny, M. and Pekna, M. (2004), Astrocyte intermediate filaments in CNS pathologies and regeneration. J. Pathol., 204: 428–437. doi: 10.1002/path.1645
- Issue published online: 19 OCT 2004
- Article first published online: 19 OCT 2004
- intermediate filaments;
- reactive gliosis;
- severe mechanical stress;
- CNS trauma;
- CNS regeneration
Astroglial cells are the most abundant cells in the mammalian central nervous system (CNS), yet our knowledge about their function in health and disease has been limited. This review focuses on the recent work addressing the function of intermediate filaments in astroglial cells under severe mechanical or osmotic stress, in hypoxia, and in brain and spinal cord injury. Recent data show that when astrocyte intermediate filaments are genetically ablated in mice, reactive gliosis is attenuated and the course of several CNS pathologies is altered, while the signs of CNS regeneration become more prominent. GFAP is the principal astrocyte intermediate filament protein and dominant mutations in the GFAP gene have been shown to lead to Alexander disease, a fatal neurodegenerative condition in humans. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.