The effects of long-term administration of methyltestosterone on the development of liver lesions in BALB/c mice
Version of Record online: 16 JUN 2005
Copyright © 1984 John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 143, Issue 3, pages 211–218, July 1984
How to Cite
Taylor, W., Snowball, S. and Lesna, M. (1984), The effects of long-term administration of methyltestosterone on the development of liver lesions in BALB/c mice. J. Pathol., 143: 211–218. doi: 10.1002/path.1711430310
- Issue online: 16 JUN 2005
- Version of Record online: 16 JUN 2005
- Manuscript Accepted: 16 MAR 1984
- Manuscript Received: 23 FEB 1984
- Smith, Kline and French Foundation (WT) and the Dorset Area Health Authority (ML)
- Anabolic androgens;
Male and female BALB/c mice were treated orally with 5 mg/kg body weight of methyltestosterone for 10 months. Age-matched control animals received no steroid treatment. The livers of all animals were examined by standard histopathological methods. Hepatocellular dysplasia was found in livers of all treated mice, but not in control animals. The extent and severity of this dysplasia showed a sex difference. Most of the male mice (55/78) developed severe dysplasia and in 23/78 the dysplasia was only moderate; the corresponding numbers for female mice were: mild, 15/71; moderate, 48/71 and severe dysplasia, 8/71. Microscopic hepatocytic nodules were found in 6/78 males and 7/71 females. Hepatocellular carcinoma was seen in one male mouse. These findings indicate that methyltestosterone appears to act as a weak total hepatocarcinogen under the experimental conditions used.