Mitochondrial and chromosomal DNA alterations in human chromophobe renal cell carcinomas
Article first published online: 16 JUN 2005
Copyright © 1992 John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 167, Issue 3, pages 273–277, July 1992
How to Cite
Kovacs, A., Storkel, S., Thoenes, W. and Kovacs, G. (1992), Mitochondrial and chromosomal DNA alterations in human chromophobe renal cell carcinomas. J. Pathol., 167: 273–277. doi: 10.1002/path.1711670303
- Issue published online: 16 JUN 2005
- Article first published online: 16 JUN 2005
- Manuscript Accepted: 2 APR 1992
- Manuscript Received: 21 FEB 1992
- Chromophobe renal cell carcinoma;
- RFLP analysis;
- mitochondrial DNA alterations
Renal cell tumours are characterized by the loss of chromosome 3p and trisomy of 5q segments (common, nonpapillary renal cell carcinoma), or by trisomy of chromosomes 7 and 17 and loss of the Y chromosome (papillary renal cell carcinoma), or by random karyotype changes and mitochondrial DNA alterations (renal oncocytoma). We have studied by means of RFLP analysis the genomic and mitochondrial DNA in 11 chromophobe renal cell carcinomas, which have a unique morphology among kidney cancers. We found a loss of the constitutional heterozygosity at chromosomal regions 3p, 5q, 17p, and 17q, a combination of allclic losses that has not been found in other types of renal cell tumours. Three of the tumours showed a gross alteration in the restriction pattern of the mitochondrial DNA. A combined morphological and genetic analysis suggests that chromophobe renal cell carcinoma is a distinct entity.